This study employs molecular dynamics simulations to investigate the ejection of nanoscale fluidic molecules through different nozzle apertures under various technology parameters. The model comprises a nozzle plate, a back plate, and water molecules filling the space between them. LAMMPS software and C + + code are used for simulations and data analysis. The research explores the impact of system temperature and nozzle aperture diameter on water droplet separation from the nozzle plate surface. It also delves into the effects of environmental parameters on nano droplet formation. The results indicate that the separation of nanoscale fluidic droplets is performed under the effect of nozzle aperture, the system temperature and ejection time but regardless of pressing forces. Additionally, the study investigates the influence of various pressing forces on the impingement of these droplets onto fixed metal plate’s surface under different system temperatures. The findings provide essential data for experimental and manufacturing processes utilizing this technology, with potential applications in fields like printing, printed circuit board manufacturing, and the development of nanoprinters, nanosprayers, and nanomachining devices.