Study on the damage of sperm induced by nickel nanoparticle exposure

Study of the mechanism of mitochondrial division and mitochondrial autophagy in the male reproductive toxicity induced by nickel nanoparticles

“…However, the research on the reproductive toxicity of NPs is still in its infancy, and further research is needed to focus on the male reproductive toxicity of Ni NPs. The exposure concentrations of mice 15,17,18,38 and cells 33,39 in this study were determined based on our previous research. Regarding the environmental dose range of Ni NP exposure, there is no exact data yet.…”

“…53 Our previous studies have found that Ni NPs induced damage in the testis tissues of SD rats and ICR male mice and caused irregular swelling of the mitochondria and mitochondrial sheaths in sperm cells and supporting cells. 17,18 Thus, it can be speculated that the reduction in sperm quality may be due to the insufficient levels of mice male reproductive hormones caused by testicular damage after exposure to Ni NPs. In addition, Ni NPs also triggered the expression of mitochondrial division, autophagy, and apoptosis-related proteins.…”

“…The management and use of animals comply with the laboratory management guidelines for animal use (National Research Council, 2016). Based on the previous research, 17 all male mice ( n = 48) were randomly divided into 6 groups: control group (0.9% normal saline), low dose group (5 mg kg −1 Ni NPs), middle dose group (15 mg kg −1 Ni NPs), high dose group (45 mg kg −1 Ni NPs), 3 μm Ni MP group (45 mg kg −1 ) and NiCl 2 group (45 mg kg −1 , based on Ni). According to the dose amount of 0.1 mL/10 g per mouse, the mice were subjected to intragastric administration weekly for 4 weeks and were weighed weekly.…”

“…13,14 Now, more and more evidence is accumulating that Ni NPs are reproductively toxic to rats and mice, as demonstrated by the abnormal reproductive hormone levels, spermatogenesis dysfunction, abnormal sperm, and testicular structural damage. 15–17 Recently, it has been confirmed that oxidative stress and apoptosis are involved in the reproductive toxicity of Ni NPs, 18 and Ni NPs can also cause damage to the functional structure of mitochondria.…”

Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production

“…As supportive references, the table below summarizes literature articles on the exposure of various NPs that induced several histological changes in the seminiferous tubules, provoking consequent reduction in the sperm number by changing the pattern of spermatogenic cells. It is therefore demonstrated that the exposure to different NPs, such as Ni NPs [108], Ag NPs and CeO2 NPs [109], induces histopathological changes in the seminiferous tubules leading to decline in sperm number (Table 2).…”