Many mines often passively select supports with a higher yield load to avoid the occurrence of support crushing and roof falling during periodic weighting. This method is not conducive to improving production efficiency or reducing mining costs, but it can ensure safe mining. An effective method for overcoming these problems is to determine the reasonable working resistance of the support according to the structural forms of the key strata in the overburden of the stope during periodic weighting. In this paper, comprehensive theoretical analysis, numerical simulation, and field observation were applied to study the discrimination of the key stratum structure (KSS) during periodic weighting and the calculation method of the support load. First, the KSS that affects the periodic weighting of the stope was classified. The “twice discrimination method” was proposed for determining the breaking form of the key strata and the articulated form of the broken blocks. On this basis, the spacing condition that determines whether adjacent key strata interact was analyzed. The discriminant conditions for synergistic breaking between the first subordinate key stratum (SKS1) and the upper key stratum were derived for the cases in which the SKS1 periodically breaks in the form of a cantilever beam, a voussoir beam, and a step beam. These conditions provide the basis for distinguishing the KSS in the overburden of the stope. In addition, mechanical models of the roof structure during periodic weighting were established, and general formulas for calculating the support loads of stopes with a single‐key‐stratum influence structure and a multikey‐stratum influence structure were presented. Finally, five fully mechanized coal faces with various mining conditions in China were considered for engineering verification. The results of this study demonstrate that the proposed method for determining the reasonable working resistance of the support is consistent with the field practice. The research results can provide a reference for roof control and support selection of stopes.