As the main friction pair of engine, the friction loss of piston-cylinder liner assembly in the working process has become the main reason of engine friction power consumption. Many species in the biological world have formed non-smooth forms of resistance reduction after thousands of years of survival and evolution. Many people have applied this non-smooth shape of drag reduction on organisms to the surface of friction pairs in construction machinery. Based on LX108 engine, the wear and erosion resistance of Scapharca subcrenata surface is applied to the piston skirt, which is the main friction pair in the engine. Nine test schemes were designed according to orthogonal test. This design selects three factors, namely, groove distribution type, groove depth and width, groove spacing, and each factor includes three levels. The macroscopic fluid lubrication state of the whole piston skirt with bionic shape is studied. Through the change of oil film thickness caused by thermal-mechanical coupling deformation of skirt, combined with the average Reynolds equation, the hydrodynamic pressure of lubricating oil, shear stress, and skirt friction force are obtained to verify the contribution of bionic shape to piston drag reduction, wear reduction, wetting increase, and friction power consumption. The simulation and test results show that the lubrication of all parts of the bionic groove piston skirt is better than that of the standard piston; When the depth and width of groove is 0.8 mm and the spacing is 10°, the thicker the oil film thickness of skirt is; The bionic piston whose oil film bearing area is 74%–87% of the standard piston has the smallest normal pressure and friction; When the upper end of the skirt is arranged with groove shape and the lower end is arranged with narrow groove shape between wide grooves, the lubrication effect is better.