This review article examines the working principles, optimal dimensions, effects of key parameters, and the results of experimental/numerical studies on cyclone separators. Investigations have been conducted on the effects of parameters such as vortex finder diameter, conical part diameter, cyclone separator diameter, cylinder height, inlet height, inlet width, vortex finder length, and cyclone total length on efficiency, performance, and pressure drop. Furthermore, the article explores current modifications and efforts to improve efficiency. These modifications include adding water nozzles, inserting ribs, employing double‐stage cyclones, incorporating additional inlets, using finned cylinder bodies, adding extra top inlets, introducing liquid jets, employing helical roof inlets, adding laminarizers, incorporating internal spiral vanes, and employing slotted vortex finders. While serving as a guide to optimize the design and performance of cyclone separators, this article emphasizes new and innovative approaches to enhance their industrial applicability. By compiling studies conducted from conceptual birth to the present, the aim of this article is to serve as a guidebook.