Study on the effectiveness and impact of pentavalent vaccination program in India and other south Asian countries

The Comparison of the Adverse Events of Pentavalent Vaccine and DPT Vaccine in 2–6 Months Infants in Iran: A National Study

“…Therefore, WHO strongly recommends global Hib Vaccination [20]. Vaccination with the Pentavalent vaccine automatically increased the coverage of Hepatitis B and Hib immunization [11].…”

“…A study in the USA showed that fever (25.8%), injection site sensitivity (15.8%) and injection site edema (10.8%) were the most remarkable adverse events of Pentavalent vaccine [9,10]. Some of the Pentavalent vaccine advantages include reducing the number of injections and syringes used, less pain and restlessness in infants, decreasing the complications of injection, ease of planning, increasing cost effectiveness and increasing the immunization coverage [11].…”

Tackling the Hepatitis B Disease Burden in India

“…105 However, there are concerns regarding the safety and tolerance of the pentavalent vaccine. 106 However, the coverage with three doses of HBV vaccine was found to be lower than similarly timed three doses of DPT vaccine. There may be several causes of the poor uptake of hepatitis B vaccine in India.…”

Comparison of adverse events following pentavalent and diphtheria‐tetanus‐pertussis vaccines among Nigerian children

“…In India and in other Asian countries (Bhutan, Vietnam, and Pakistan) following the introduction of a pentavalent vaccine similar to that in Nigeria, there were reportedly severe reactions that were said to be attributable to the vaccine although investigations did not confirm causality. 5 However, in Ghana and in Latin America that also use a vaccine combination similar to that in Nigeria, the vaccine was reported to be safe. 6,7 In the few studies that have documented vaccine reactions of Nigerian children to the pentavalent vaccine and the one from Ghana, there was no comparison between reactions to pentavalent and DTwP vaccines.…”