At this stage, I am very grateful for what I have loosed and achieved in the last three years, which, to someone may be negligible or even miserable, but to me is constructive and fruitful. It not reasonable to image that I could be here when I first came to Singapore as an innocent big boy, so what I want to say most here is THANKS, to all the people and things I met in these years. First and foremost, I would like to express my sincere appreciation and deepest respect to my supervisor Prof. Fan Hongjin and co-supervisor Prof. Zhang Hua for their meaningful guidance, creative educational way and firmly support to me throughout my Ph.D. years-not only on my research project, but even on my own personal problems. From them I could not only learn a lot on science, how to find problems and to solve them, how to try new things from fails, but also I could understand more deeply on life, life is just like experiments, or experiments are just like life. I also thank my colleagues, Dr.