Study on the inhibitory effects of Korean medicinal plants and their main compounds on the 1,1-diphenyl-2-picrylhydrazyl radical

Methyl gallate and chemicals structurally related to methyl gallate protect human umbilical vein endothelial cells from oxidative stress

“…meGAL is a phytochemical from various species including Meliaceae, Rosa Rugosa and Galla Rhois, and its derivative (-)-epigallocatechin gallate (EGCG) is a major pytochemical of green tea, well known antioxidative beverage (Chen and Zhang, 2003). The radical scavenging effect and inhibition of LPO have been reported as major activities of meGAL (Westenburg et al, 2000;Galato et al, 2001;Cho et al, 2003). In addition, meGAL possesses the biological activities including antiplatelet activity (Lim et al, 2004), protection of DNA damaging against oxidative stress (Hsieh et al, 2004), protection of lung injury induced by phosgene (Sciuto and Moran, 2001), attenuation of diabetic oxidative stress (Cho et al, 2004) and antiapoptotic activity (Sohi et al, 2003).…”

“…The persistent production of abnormally large amount of ROS or RNS, however, Methyl gallate and chemicals structurally related to methyl gallate protect human umbilical vein endothelial cells from oxidative stress may lead to persistent changes in signal transduction and gene expression, which in turn may give rise to certain diseases. meGAL is known as one of major antioxidants (Westenburg et al, 2000;Galato et al, 2001;Cho et al, 2003;Sohi et al, 2003). meGAL is a phytochemical from various species including Meliaceae, Rosa Rugosa and Galla Rhois, and its derivative (-)-epigallocatechin gallate (EGCG) is a major pytochemical of green tea, well known antioxidative beverage (Chen and Zhang, 2003).…”

Anti-Inflammatory Effects of Hexane Fraction from White Rose Flower Extracts via Inhibition of Inflammatory Repertoires

“…The rose (genus Rosa), allied to its use as a source of aromatic oils for the perfume industry, has been an alternative model for pharmaceutical candidates to treat diabetes mellitus, pain, and infl ammatory diseases (Cho et al, 2003;Ng et al, 2005). Previously, we reported that the hexane fraction from white rose fl owers, which may contain high amounts of…”

“…Moreover, natural anti-infl ammatory or immunomodulatory plant metabolites, which are abundant in fractionated extracts, have therapeutic effects against various chronic diseases, by inducing or suppressing specifi c cellular infl ammatory activities and the associated molecular signaling pathways (Aravindaram and Yang, 2010). Some polyphenols, such as catechines from green tea, appear to be the primary bioactive compounds in the suppression of key cytokines that are secreted during the infl ammation cascade (De Mjia et al, 2009;Gosslau et al, 2011a).The rose (genus Rosa), allied to its use as a source of aromatic oils for the perfume industry, has been an alternative model for pharmaceutical candidates to treat diabetes mellitus, pain, and infl ammatory diseases (Cho et al, 2003;Ng et al, 2005). Previously, we reported that the hexane fraction from white rose fl owers, which may contain high amounts of…”

Tyrosinase Inhibition, 2,2-Diphenyl-1-Picrylhydrazyl Radical Scavenging Activity, and Phytochemical Screening of Fractions and Ethanol Extract From Leaves and Stem Bark of Matoa (Pometia Pinnata)

“…Screening results performed by Cho et al showed that the methanol extract of some Rosaceae plant family materials had a DPPH radical scavenging activity that was very strong, with an IC 50 value below 10 µg/mL, and the main content in the plant extract was the polyphenolic compounds [22]. The polyphenolic compounds isolated from the plant had been investigated to have strong DPPH scavenging activity, including condensed tannins, quercetin, catechins, and kaempferol.…”