Study on the Interaction between the Characteristics of Retinal Microangiopathy and Risk Factors for Cerebral Small Vessel Disease

Tang, Qian; Yang, Zebin; Li, Siou; Wu, Meini; Guo, Yongming; Zhao, Weina; Yin, Changhao

doi:10.1155/2022/9505945

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…There is mounting evidence that retinal biomarkers are related to the emergence of various CSVD imaging features, which is important for the increased risk of cognitive impairment ( 20 , 34 ). It has been reported that the CSVD burden was associated with a wider CRVE, a smaller AVR, and a higher incidence of vessel tortuosity ( 35 ). A further study indicated that cerebral WMH might be partially predicted by non-invasive fundus photography via deep learning algorithm ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

The association of global vessel width with cognitive decline and cerebral small vessel disease burden in the KaiLuan study

Li,

Hui,

et al. 2024

Quant Imaging Med Surg

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Background As the retinal microvasculature shares similarities with the cerebral microvasculature, numerous studies have shown that retinal vascular is associated with cognitive decline. In addition, several population-based studies have confirmed the association between retinal vascular and cerebral small vessel disease (CSVD) burden. However, the association of retinal vascular with CSVD burden as well as cognitive function has not been explored simultaneously. This study investigated the relations of retinal microvascular parameters (RMPs) with CSVD burden and cognitive function. Methods We conducted a cross-sectional study of participants in the KaiLuan study. Data were collected from subjects aged ≥18 years old who could complete retinal photography and brain magnetic resonance imaging (MRI) between December 2020 to October 2021 in the Kailuan community of Tangshan. RMPs were evaluated using a deep learning system. The cognitive function was measured using the Montreal Cognitive Assessment (MoCA). We conducted logistic regression models, and mediation analysis to evaluate the associations of RMPs with CSVD burden and cognitive decline. Results Of the 905 subjects (mean age: 55.42±12.02 years, 54.5% female), 488 (53.9%) were classified with cognitive decline. The fractal dimension (FD) [odds ratio (OR), 0.098, 95% confidence interval (CI): 0.015–0.639, P=0.015] and global vein width (OR: 1.010, 95% CI: 1.005–1.015, P<0.001) were independent risk factors for cognitive decline after adjustment for potential confounding factors. The global artery width was significantly associated with severe CSVD burden (OR: 0.985, 95% CI: 0.974–0.997, P=0.013). The global vein width was sightly associated with severe CSVD burden (OR: 1.005, 95% CI: 1.000–1.010, P=0.050) after adjusting for potential confounders. The multivariable-adjusted odds ratios (95% CI) in highest tertile versus lowest tertile of global vein width were 1.290 (0.901–1.847) for cognitive decline and 1.546 (1.004–2.290) for severe CSVD burden, respectively. Moreover, CSVD burden played a partial mediating role in the association between global vein width and cognitive function (mediating effect 6.59%). Conclusions RMPs are associated with cognitive decline and the development of CSVD. A proportion of the association between global vein width and cognitive decline may be attributed to the presence of CSVD burden.

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Section: Discussionmentioning

confidence: 99%

The association of global vessel width with cognitive decline and cerebral small vessel disease burden in the KaiLuan study

Li,

Hui,

et al. 2024

Quant Imaging Med Surg

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“…15 Previous studies of imaging markers of SVD-related injuries were mainly concentrated on the intracranial, including retinal microvascular diseases. 16 However, we are not aware of studies in which the imaging manifestations of SVD in spinal cord injuries have specifically been investigated. In fact, we are not aware of any reports of spinal cord SVD.…”

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confidence: 99%

Association of Mean Upper Cervical Spinal Cord Cross-Sectional Area With Cerebral Small Vessel Disease: A Community-Based Cohort Study

Meng,

Wang,

Zhu

et al. 2024

Stroke

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BACKGROUND: The purpose of this study was to investigate the association between the mean upper cervical spinal cord cross-sectional area (MUCCA) and the risk and severity of cerebral small vessel disease (CSVD). METHODS: Community-dwelling residents in Lishui City, China, from the cross-sectional survey in the PRECISE cohort study (Polyvascular Evaluation for Cognitive Impairment and Vascular Events) conducted from 2017 to 2019. We included 1644 of 3067 community-dwelling adults in the PRECISE study after excluding those with incorrect, incomplete, insufficient, or missing clinical or imaging data. Total and modified total CSVD scores, as well as magnetic resonance imaging features, including white matter hyperintensity, lacunes, cerebral microbleeds, enlarged perivascular spaces, and brain atrophy, were assessed at the baseline. The Spinal Cord Toolbox was used to measure the upper cervical spinal cord cross-sectional area of the C1 to C3 segments of the spinal cord and its average value was taken as MUCCA. Participants were divided into 4 groups according to quartiles of MUCCA. Associations were analyzed using linear regression models adjusted for age, sex, current smoking and drinking, medical history, intracranial volume, and total cortical volume. RESULTS: The means±SD age of the participants was 61.4±6.5 years, and 635 of 1644 participants (38.6%) were men. The MUCCA was smaller in patients with CSVD than those without CSVD. Using the total CSVD score as a criterion, the MUCCA was 61.78±6.12 cm 2 in 504 of 1644 participants with CSVD and 62.74±5.94 cm 2 in 1140 of 1644 participants without CSVD. Using the modified total CSVD score, the MUCCA was 61.81±6.04 cm 2 in 699 of 1644 participants with CSVD and 62.91±5.94 cm 2 in 945 of 1644 without CSVD. There were statistical differences between the 2 groups after adjusting for covariates in 3 models. The MUCCA was negatively associated with the total and modified total CSVD scores (adjusted β value, −0.009 [95% CI, −0.01 to −0.003] and −0.007 [95% CI, −0.01 to −0.0006]) after adjustment for covariates. Furthermore, the MUCCA was negatively associated with the white matter hyperintensity burden (adjusted β value, −0.01 [95% CI, −0.02 to −0.003]), enlarged perivascular spaces in the basal ganglia (adjusted β value, −0.005 [95% CI, −0.009 to −0.001]), lacunes (adjusted β value, −0.004 [95% CI, −0.007 to −0.0007]), and brain atrophy (adjusted β value, −0.009 [95% CI, −0.01 to −0.004]). CONCLUSIONS: The MUCCA and CSVD were correlated. Spinal cord atrophy may serve as an imaging marker for CSVD; thus, small vessel disease may involve the spinal cord in addition to being intracranial.

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Effect of blood pressure variability on hypertensive retinopathy

Jiao

Zhang

2023

Clinical and Experimental Hypertension

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Study on the Interaction between the Characteristics of Retinal Microangiopathy and Risk Factors for Cerebral Small Vessel Disease

Cited by 4 publications

References 38 publications

The association of global vessel width with cognitive decline and cerebral small vessel disease burden in the KaiLuan study

The association of global vessel width with cognitive decline and cerebral small vessel disease burden in the KaiLuan study

Association of Mean Upper Cervical Spinal Cord Cross-Sectional Area With Cerebral Small Vessel Disease: A Community-Based Cohort Study

Effect of blood pressure variability on hypertensive retinopathy

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