Study on the mechanism of oxygen radical-induced inflammation

Sato, Masao; Tsuruo, Takashi; Oribe, Motohiro; Tomooka, Kazuhisa; Nobunaga, Masashi; Nakagami, Keiji

doi:10.2492/jsir1981.2.4_367

Cited by 9 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effects of TFDG tended to be higher than those of 3‐TF. The excess production of superoxide anion radicals and nitric oxide by macrophages and neutrophils is thought to provoke inflammation in the neighbouring tissues 20, 21. The enhancement of serum antioxidant activities in mice administered theaflavins is thought to contribute to the anti‐allergic effects.…”

Section: Resultsmentioning

confidence: 99%

Preventive effects of black tea theaflavins against mouse type IV allergy

Yoshino

Yamazaki

Sano

2010

J. Sci. Food Agric.

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Preventive effects of black tea theaflavins against mouse type IV allergy

Yoshino

Yamazaki

Sano

2010

J. Sci. Food Agric.

View full text Add to dashboard Cite

show abstract

“…4) It was reported that some active oxygen species produced in the Fenton reaction or HarberWeiss reaction, such as superoxide anion radicals and hydrogen peroxide, play important roles in the inflammatory process. 5) Antioxidants, such as superoxide dismutase and tea catechins, are known to suppress inflammation in a rat arthritis model and in a mouse model of contact hypersensitivity.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Antiinflammatory Activities of Oregano Extract

Yoshino

Higashi

Koga

2006

JOURNAL OF HEALTH SCIENCE

View full text Add to dashboard Cite

The antioxidant activity of the crude extract prepared from oregano (Origanum vulgare L.) and its antiinflammatory activities in mouse models of stressinduced gastritis and contact hypersensitivity were investigated. Oregano extract was a substrate for peroxidase, similar to phenol. Oregano extract exhibited iron-reducing activity, although its strength was approximately one-fifth of that of ascorbic acid. Oral administration of oregano extract significantly prevented mouse gastritis induced by cold-restraint stress. Percutaneous administration of oregano extract also significantly prevented mouse contact hypersensitivity induced by oxazolone. These antiinflammatory activities of oregano extract tended to be weaker than those of hydrocortisone. The antioxidant activities of oregano extract appear to contribute to its preventive effects against inflammatory diseases, such as stressinduced gastritis and contact hypersensitivity in mice.

show abstract

“…Recently, an acute foot-edema of the rat was successfully induced by combined injection of xanthine oxidase (XOD) and hypoxanthine (HPX) , a superoxide generation system, into the hind foot paw; this edema was inhibited by allopurinol, an inhibitor of XOD, or by SOD and catalase (13). XOD and HPX injection are also reported to increase the permeability of blood vessels and PMN infiltration in rat skin (14) and in hamsters (15). In this study, we examined skin erythema induced by intradermal injection of XOD and HPX into guinea pigs and observed the time course of erythema macroscopically and histologically in relationship to the age of the animals as well as to the SOD activity of the skin.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Reactive Oxygen Species‐induced Skin Erythema and Superoxide Dismutase Activities in Guinea Pigs

Yoshioka

Imamura

1987

The Journal of Dermatology

View full text Add to dashboard Cite

Reactive oxygen species (ROS)-induced skin erythema was produced by injection of xanthine oxidase (XOD) and hypoxanthine (HPX), an R05-producing system, into guinea pig skin. The clinical course of the erythema was examined in relationship to the age of the animal as well as to superoxide dismutase (SOD) activity of the skin, The R05-induced skin erythema reached a peak 24 hr after injection of XOD and HPX macroscopically and histologicallywith the reduction of skin SOD activity, and the severityof erythema was age-dependent. The increased severityof the skin erythema with age was related to the reduction of the skin SOD activities after XOD plus HPX injection. This skin erythema will provide a good model for the investigation of oxidative tissue injuries observed in several skin disorders.

show abstract

Study on the mechanism of oxygen radical-induced inflammation

Cited by 9 publications

References 0 publications

Preventive effects of black tea theaflavins against mouse type IV allergy

Preventive effects of black tea theaflavins against mouse type IV allergy

Antioxidant and Antiinflammatory Activities of Oregano Extract

Mechanisms of Reactive Oxygen Species‐induced Skin Erythema and Superoxide Dismutase Activities in Guinea Pigs

Contact Info

Product

Resources

About