Study on the Mechanism of Compound Kidney-Invigorating Granule for Osteoporosis based on Network Pharmacology and Experimental Verification

Lv, Hao; Wang, Jiuxiang; Zhu, Yujun; Jiang, Ting

doi:10.1155/2022/6453501

Cited by 1 publication

(2 citation statements)

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“…Figure 3 shows the docking visualization of five molecules and MAPK14. The binding energy of less than -5 kcal/mol indicates a stable binding between the ligands and receptors [ 15 , 16 ]. The results reveal that five molecules can bind well with MAPK14 and hub targets.…”

Section: Resultsmentioning

confidence: 99%

“…KEGG pathways enrichment was conducted to predict the potential anti-OP pathways of five molecules, respectively. The KEGG pathway involved in human disease section was removed because OP was caused by basic biological dysfunctions [ 16 ]. Figure 5(a) shows 18 pathways were significantly enriched from ARS-OP targets, 55 pathways from DHA-OP targets, 32 pathways from ART-OP targets, and 19 pathways from ARM-OP targets, 40 pathways from ARE-OP targets.…”

Section: Resultsmentioning

confidence: 99%

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Exploring the Potential Mechanism of Artemisinin and Its Derivatives in the Treatment of Osteoporosis Based on Network Pharmacology and Molecular Docking

Liu

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. This study is aimed at predicting and contrasting the mechanisms of artemisinin (ARS), dihydroartemisinin (DHA), artesunate (ART), artemether (ARM), and arteether (ARE) in the treatment of osteoporosis (OP) using network pharmacology and molecular docking. Methods. The targets of ARS, DHA, ART, ARM, and ARE were obtained from the SwissTargetPrediction. The targets related to OP were obtained from the TTD, DrugBank, Genecards, and DisGeNet databases. Then, the anti-OP targets of ARS, DHA, ART, ARM, and ARE were obtained and compared using the Venn diagram. Afterward, the protein-protein interaction (PPI) networks were built using the STRING database, and Cytoscape was used to select hub targets. Moreover, molecular docking validated the binding association between five molecules and hub targets. Finally, GO enrichment and KEGG pathway enrichment were conducted using the DAVID database. The common pathways of five molecules were analysed. Results. A total of 28, 37, 36, 27, and 33 anti-OP targets of ARS, DHA, ART, ARM, and ARE were acquired. EGFR, EGFR, CASP3, MAPK8, and CASP3 act as the top 1 anti-OP targets of ARS, DHA, ART, ARM, and ARE, respectively. MAPK14 is the common target of five molecules. All five molecules can bind well with these hubs and common targets. Meanwhile, functional annotation showed that MAPK, Serotonergic synapse, AMPK, prolactin, and prolactin signaling pathways are the top 1 anti-OP pathway of ARS, DHA, ART, ARM, and ARE, respectively. IL-17 signaling pathway and prolactin signaling pathway are common anti-OP pathways of five molecules. Besides, GO enrichment showed five biological processes and three molecular functions are common anti-OP mechanisms of five molecules. Conclusion. ARS, DHA, ART, ARM and ARE can treat OP through multi-targets and multi pathways, respectively. All five molecules can treat OP by targeting MAPK14 and acting on the IL-17 and prolactin signaling pathways.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%