Study on the mechanism of andrographolide activation

Abstract

Andrographolide is a natural antibiotic that has the ability to dispel heat, detoxify, reduce inflammation, and relieve pain. Recent research has shown that it can exert anti-inflammatory effects via multiple pathways and multiple targets (mediated by NF-κB, JAK/STAT, T cell receptor, and other signaling pathways). It can inhibit human lung cancer cells, colon cancer cells, osteosarcoma cells, and other tumor cells, as well as reduce bacterial virulence and inhibit virus-induced cell apoptosis. It can also regulate inflammatory mediator expression to protect the nervous system and effectively prevent mental illness. Additionally, andrographolide regulates the immune system, treats cardiovascular and cerebral vascular diseases, protects the liver, and the gallbladder. It is clear that andrographolide has a huge range of potential applications. The mechanism of andrographolide’s anti-inflammatory, antibacterial, antiviral, and nervous system defense in recent years have been reviewed in this article.

Construction and validation of an angiogenesis-related lncRNA prognostic model in lung adenocarcinoma

“…Angiogenesis is the process of germination from existing blood vessels to form new ones, which plays a crucial role in the carcinogenesis of lung adenocarcinoma ( Wang Y. et al, 2019 ). Numerous studies have shown the prognostic value of ARGs in cancer ( Zheng et al, 2021 ; Cai et al, 2022 ; Tao et al, 2022 ), where Sun et al found that POSTN may ultimately affect the prognosis of patients with LUAD by altering the immune microenvironment ( Sun et al, 2022 ), and in our study, 55 ARGs associated with LUAD were obtained from 549 samples in the TCGA database. In addition, we also identified LUAD-related DE-lncRNAs and obtained 50 LUAD-related DE-lncRNAs.…”

Effect of traditional Chinese medicine in osteosarcoma: Cross-interference of signaling pathways and potential therapeutic targets

“…Hederoside C P. koreana MG-63, U2OS [100] Salidroside Rhodiola rosea L. U2OS, MG-63 [101] Tubocapsenolide A Tubocapsicum anomalum SHP-2 [102] Andrographolide Andrographis paniculata U2OS [103] Pacilitaxel Taxus wallichiana var. chinensis (Pilger) Florin U2OS, MG-63 [104] Resveratrol Veratrum album MNNG/HOS, MG-63 [105] β-caryophyllene Dianthus chinensis L. MG-63 [106] Sodium cantharidate Mylabris phalerata Pallas MG-63 [107] Tanshinone I Salvia miltiorrhiza Bunge U2OS, MOS-J [108,109] Notch pathway Cinobufagin Bufo raddei U2OS, MG-63 [110] Curcumin Curcuma longa L. U2OS [92,111] Cannabinoids Cannabis sativa L. MG-63 [112] Dihydroartemisinin Artemisia caruifolia Buch.-Ham.…”

“…Zhu et al [102] found that agrimonia lactone activated the phosphatase activity of Src homology 2 phosphatase 2 (SHP-2), thereby inhibiting the JAK/STAT3 signaling pathway, helping to inhibit the proliferation of OS cells and promote the apoptosis of OS cells. Andrographolide has the effects of clearing heat and detoxicatin, reducing inflammation and relieving pain, while Cai et al [103] found that this compound could reduce the phosphorylation level of STAT1/2 by inhibiting the activity of JAK2/STAT3 signaling pathway, reduce the release of pro-inflammatory cytokines or mediators (including TNF-α, IL-6, IL-1βand IL-10), so as to reduce the degree of paw swelling in mice, and block the progression of OS. Zhang et al [104] found that paclitaxel could inhibit OS cell growth as well as induce OS cell apoptosis by mediating the SHP-1/JAK2/STAT3 signaling pathway, so as to delay the progression of OS to some extent.…”

Phytochemicals against Osteoarthritis by Inhibiting Apoptosis

“…ex Nees] (AG) is a natural antibiotic and the main active component of Andrographis paniculata. It can remove heat, expel toxins, relieve inflammation and pain, and effectively treat inflammatory diseases [104]. AG shows a wide range of biological activities, which has been a hot research field for many years [105].…”