Study on the Mechanisms of Banxia Xiexin Decoction in Treating Diabetic Gastroparesis Based on Network Pharmacology

Wu, Tingchao; Yue, Rensong; Li, Liang; He, Mingmin

doi:10.1007/s12539-020-00389-1

Cited by 11 publications

(7 citation statements)

References 83 publications

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“…Studies indicated that the extracts and compounds from Traditional Chinese medicines suppressed the EMT (Zhao and Wei, 2015), proliferation and migration of different cancer cells by inhibiting CFL1 signaling pathway in different cancer cells (Wang et al, 2017;Liu et al, 2018). The Garcinia species from Guttiferae family have been studied for nearly 80 years (Lu et al, 2020;Wu et al, 2020). The major compounds of these species were xanthones, polycyclic polyprenylated acylphloroglucinols (PPAPs) and benzophenones (Han and Xu, 2009), which show a variety of biological functions (Wang et al, 2008;Xia et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Nujiangexanthone A Inhibits Hepatocellular Carcinoma Metastasis via Down Regulation of Cofilin 1

Zhang

Chai

Kong

et al. 2021

Front. Cell Dev. Biol.

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Hepatocellular carcinoma (HCC) is one of the malignant tumors with poor prognosis. High expression level of cofilin 1 (CFL1) has been found in many types of cancers. However, the role of CFL1 in HCC hasn’t been known clearly. Here, we found that CFL1 was up regulated in human HCC and significantly associated with both overall survival and disease-free survival in HCC patients. Nujiangexanthone A (NJXA), the caged xanthones, isolated from gamboge plants decreased the expression of CFL1, which also inhibited the migration, invasion and metastasis of HCC cells in vitro and in vivo. Down regulation of CFL1 inhibited aggressiveness of HCC cells, which mimicked the effect of NJXA. Mechanism study indicated that, knockdown of CFL1 or treatment with NJXA increased the level of F-actin and disturbed the balance between F-actin and G-actin. In conclusion, our findings reveal the role of CFL1 in HCC metastasis through the CFL1/F-actin axis, and suggest that CFL1 may be a potential prognostic marker and a new therapeutic target. NJXA can effectively inhibit the metastasis of HCC cells by down regulating the expression of CFL1, which indicates the potential of NJXA for preventing metastasis in HCC.

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Section: Introductionmentioning

confidence: 99%

Nujiangexanthone A Inhibits Hepatocellular Carcinoma Metastasis via Down Regulation of Cofilin 1

Zhang

Chai

Kong

et al. 2021

Front. Cell Dev. Biol.

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“…The TCM method is noninvasive and inexpensive and appears to be effective and promising based on clinical practice and some preliminary evidence. A large number of studies have demonstrated the efficacy of TCM decoction in the treatment of DGP[ 28 - 31 ], however, due to the wide variety of drugs and the lack of randomized controlled trials(RCTs) comparing drugs, it is inconvenient for clinicians to choose drugs, the TCM decoctions with the greatest effectiveness against DGP in adults have not been found.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and safety of traditional Chinese medicine decoction for diabetic gastroparesis: A network meta-analysis

Zhang¹,

Zhang²,

Miao³

et al. 2023

World J Diabetes

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BACKGROUND Diabetic gastroparesis (DGP) is a prevalent complication of diabetes that impairs people's quality of life and places a significant financial burden on them. The gastrointestinal symptoms of DGP patients can be improved by several Traditional Chinese Medicine (TCM) decoctions that have been shown to be effective in treating the disease. There are still many unanswered questions regarding the identification of appropriate therapeutic agents for the treatment of DGP in clinical practice. AIM To analyze the efficacy of several TCM decoctions in the treatment of DGP using Bayesian network meta-analysis for reference. METHODS PubMed, EMBASE, Cochrane Library, Web of Science, China National Kno-wledge Infrastructure, The China Biology Medicine DVD, Wanfang, and CQVIP were searched from inception to September 17, 2022, to collect randomized controlled trials (RCTs) about TCM decoctions for DGP. Clinical effects and symptom scores were the primary outcomes. Additionally, we assessed motilin (MOT), somatostatin (SS), gastrin (GAS), gastric emptying rate, gastric emptying time, and adverse drug events as secondary outcomes. RESULTS A total of 67 eligible RCTs involving 4790 DGP patients and 7 TCM decoctions were included. The results of network meta-analysis (NMA) and surface under the cumulative ranking curve showed that with western medicine (WM) as a common control, the Banxia Xiexin Decoction (BXXD) + WM was most effective in clinical effects and enhancing early satiety scores; the Simo decoction (SMD) + WM was most effective in improving nausea and vomiting scores and anorexia scores, bloating scores; the Chaishao Liujunzi Decoction (CSLJD) was most effective in MOT, the Zhishi Xiaopi Decoction (ZSXPD) was most effective in SS and upgrading emptying rate; the Jianpi Xiaozhi Decoction was most effective in GAS; the CSLJD + WM was most effective in improving gastric emptying time. CONCLUSION These NMA results suggest that the BXXD + WM and SMD + WM may be one of the potential optimal treatments. Due to various limitations, further large-sample, double-blind, multi-center randomized RCTs are needed.

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“…The role of Cordyceps in the treatment of diabetic nephropathy was elucidated by network pharmacology to be comprehensive via multiple pathways [ 18 ]. The molecular mechanisms of Ban-Xia-Xie-Xin decoction in treating DGP were affirmed to be a complex network with multitarget and multipathway by network pharmacology [ 19 ]. Hence, to better understand the effective components and the molecular mechanisms of the therapeutic effects of HL-BX on DGP, utilization of network pharmacology technology to seek the components and potential pathways of HL-BX in the treatment of DGP is completely consistent with the concept of “Disease-Gene-Target-Medicine” and the holistic view of TCM.…”

Section: Introductionmentioning

confidence: 99%

Effects and Components of Herb Pair Huanglian-Banxia on Diabetic Gastroparesis by Network Pharmacology

Liang

Zhang

Jiang

et al. 2021

BioMed Research International

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Diabetic gastroparesis (DGP) is a serious and chronic complication of long-standing diabetes mellitus, which brings a heavy burden to individuals and society. Traditional Chinese medicine (TCM) is considered a complementary and alternative therapy for DGP patients. Huanglian (Coptidis Rhizoma, HL) and Banxia (Pinelliae Rhizoma, BX) combined as herb pair have been frequently used in TCM prescriptions, which can effectively treat DGP in China. In this article, a practical application of TCM network pharmacological approach was used for the research on herb pair HL-BX in the treatment of DGP. Firstly, twenty-seven potential active components of HL-BX were screened from the TCMSP database, and their potential targets were also retrieved. Then, the compound-target network and PPI network were constructed from predicted common targets, and several key targets were found based on the degree of the network. Next, GO and KEGG enrichment analyses were conducted to obtain several significantly enriched terms. Finally, the experimental verification was made. The results demonstrated that network pharmacological approach was a powerful means for identifying bioactive ingredients and mechanisms of action for TCM. Network pharmacology provided an effective strategy for TCM modern research.

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Study on the Mechanisms of Banxia Xiexin Decoction in Treating Diabetic Gastroparesis Based on Network Pharmacology

Cited by 11 publications

References 83 publications

Nujiangexanthone A Inhibits Hepatocellular Carcinoma Metastasis via Down Regulation of Cofilin 1

Nujiangexanthone A Inhibits Hepatocellular Carcinoma Metastasis via Down Regulation of Cofilin 1

Effectiveness and safety of traditional Chinese medicine decoction for diabetic gastroparesis: A network meta-analysis

Effects and Components of Herb Pair Huanglian-Banxia on Diabetic Gastroparesis by Network Pharmacology

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