Study on the number of decision variables in design and optimization of Varicol process

Yao, Chuanyi; Tang, Shaokun; Yao, Huan; Tadé, Moses O.; Xu, Yanyan

doi:10.1016/j.compchemeng.2014.05.004

Cited by 11 publications

(2 citation statements)

References 22 publications

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“…The outstanding performance of the VariCol process was confirmed by experimental and computational studies [62][63][64][65][66]. Gong et al obtained 29 % higher productivity and the same purity as conventional SMB for the separation of guaifenesin enantiomers [62].…”

Section: Manipulations During Shiftsmentioning

confidence: 92%

“…To optimize the design of the VariCol operation, Yao et al considered the number of switches of four ports during a switching period and concluded that the minimum number of switches generates the best performance . Based on this simple‐shifting scheme (SSS), the dodecahedron model was proposed to optimize the VariCol process .…”

Section: Operating Strategies To Extend the Potential Of Conventionalmentioning

confidence: 99%

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Advanced Operating Strategies to Extend the Applications of Simulated Moving Bed Chromatography

et al. 2017

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Chromatographic separation with solid stationary and fluid mobile phases is widely used to isolate and purify compounds. One of the most productive improvements in preparative chromatography is the simulated moving bed (SMB) process, which enables continuous feed supply and product removal by periodic operation of a multicolumn to simulate a countercurrent flow between the phases. The SMB process produces high‐purity compounds, even with low selectivity, and offers higher productivity and lower eluent consumption than batch chromatography. Recently, intensive efforts have been made to expand the range of applications through the design, modeling, and optimization of the SMB process to produce advanced operating strategies, which are described and evaluated in this review.

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