Study on the relation between tissues pathologies and traditional chinese medicine syndromes in knee osteoarthritis: Medical image diagnostics by preoperative X-ray and surgical arthroscopy

Tian, Xiangdong; Zhu, Guangyu; Wang, Jian; Wang, Qingfu; Guan, Lei; Tan, Yetong; Xue, Zhenxiang; Qin, Lanfang; Zhang, Jing

doi:10.3233/xst-160567

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…The relationship between TM pattern descriptors and CM diagnosis has been an established research topic within the East Asian TM community (Lu and Chen, 2011;Lu et al, 2012). Studies have shown the relationship of specific TM pattern descriptors with a diverse array of CM presentations, including knee osteoarthritis (Tian et al, 2016) and openangle glaucoma (Yang et al, 2018). However, before the advent of the standardized TM ICD-11 pattern descriptors as in this study, it has been difficult to conduct a comparative analysis between differing medical traditions with unique terminology and classifications, and such as between Kampo and traditional Chinese medicine.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Conventional Medicine Chapters in ICD-10 and Kampo Pattern Diagnosis: A Cross-Sectional Study

Wu¹,

Le²,

Maeda-Minami³

et al. 2021

Front. Pharmacol.

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Objectives: The newest revision to the International Classification of Diseases, the 11th edition (ICD-11) includes disease classifications from East Asian medicine, including traditional Japanese medicine (Kampo medicine). These disease classifications allow for comparisons between disease classifications from conventional medicine and Kampo medicine.Design/Location/Subjects/Interventions: This is an exploratory, cross-sectional study exploring the relationship between conventional medicine diagnoses and Kampo medicine diagnoses at a large Kampo clinic in Japan. Patients were seen from October 1st, 2014 to June 30th, 2019 and were 20 years of age or older.Outcome measures: Patients presented with one or more conventional medicine ICD-10 codes into the clinic and were given one descriptor from the ICD-11 within the heat-cold module, excess-deficiency module, and an optional body constituents module. The distribution of these Kampo medicine codes was examined in relation to conventional medicine chapters.Results: 1,209 patients were included in our final analysis. Patient number, ages, sex ratio, and BMI varied within conventional medicine ICD-10 chapters and Kampo medicine descriptor codes. Certain conventional medicine chapters are related to specific Kampo medicine descriptor codes, such as chapter IV (endocrine, nutritional, and metabolic diseases) with excess, heat, and kidney qi deficiency.Conclusion: The advent of the ICD-11 allows for systematic, standardized comparisons between Kampo medicine, and contemporary medicine. In this exploratory study, our findings support the independence of Kampo medicine pattern descriptors with ICD-10 conventional medicine chapters. Code overrepresentations in relation to conventional medicine diseases and by age and sex should be an area of future investigation to best understand how to synergize and improve patient care.

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Section: Discussionmentioning

confidence: 99%

Relationship Between Conventional Medicine Chapters in ICD-10 and Kampo Pattern Diagnosis: A Cross-Sectional Study

Wu¹,

Le²,

Maeda-Minami³

et al. 2021

Front. Pharmacol.

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“…It has been widely used to treat various bone diseases in China for several decades [ 7 ]. According to TCM syndromes, the deficiency and blood stasis are regarded as the main pathogenesis of OA [ 8 ]. Of note, BSHX has been previously shown to dilate blood vessels and improve microcirculation, thereby modifying platelet aggregation, protecting vascular endothelial cells, and resisting oxidation [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

BushenHuoxue formula promotes osteogenic differentiation via affecting Hedgehog signaling pathway in bone marrow stem cells to improve osteoporosis symptoms

Chen,

Wei,

Shi

et al. 2023

PLoS ONE

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Background The BushenHuoxue formula (BSHX) has been previously demonstrated to ameliorate osteoporosis, but the mechanisms underlying this phenomenon are currently unclear. The present study aims at investigating the mechanisms that BSHX induces osteogenesis. Methods We established an osteoporosis model in rats by bilateral ovariectomy and then treated the rats with an osteogenic inducer (dexamethasone, β-sodium glycerophosphate and Vitamin C) and BSHX. After that, bone marrow density and histopathological bone examination were evaluated by using HE staining and immunohistochemistry, respectively. We also assessed the differentiation of bone marrow mesenchymal stem cells (BMSCs) into osteoblasts by using immunofluorescence staining. ALP, BMP, and COL1A1 levels were determined by ELISA. We identified genes involved in pathogenesis of osteoporosis through Gene Expression Omnibus (GEO) database and subsequently selected Hedgehog signaling-related genes Shh, Ihh, Gli2, and Runx2 for assessment via qRT-PCR and ELISA, Western blotting. Network pharmacology analysis was performed to identify bioactive metabolites of BSHX. Results BSHX treatment in osteoporosis model rats promoted tightening of the morphological structure of the trabecular bone and increased the bone mineral density (BMD). BSHX also increased levels of osteoblast makers ALP, BMP, and COL1A1. Additionally, bioinformatics analysis of the GEO dataset showed that Hedgehog signaling pathway was involved in pathogenesis of osteoporosis, especially related genes Shh, Ihh, Gli2, and Runx2. Remarkably, BHSX upregulated these genes indispensably involved in the osteogenesis-related Hedgehog signaling pathway in both bone tissue and BMSCs. Importantly, we identified that quercetin was the active compounds that involved in the mechanism of BSHX-improved OP via affecting Hedgehog-related genes. Conclusion Our results indicate that BSHX promotes osteogenesis by improving BMSC differentiation into osteoblasts via increased expression of Hedgehog signaling-related genes Shh, Ihh, Gli2, and Runx2, and quercetin was the bioactive compound of BSHX.

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“…TCM believes that KOA is associated with constitution, environment, diet, exercise and other factors, and the occurrence and development of the disease is a progressive process. TCM believes that dampness easily invades the body, especially in damp environments or living in cold regions [6] . Dampness can enter the body through the skin, accumulate in the joints, hinder the circulation of qi and blood, and lead to symptoms such as joint pain, swelling and stiffness.…”

mentioning

confidence: 99%

Integration of Traditional Chinese Medicine and Western Medicine in the Treatment of Knee Osteoarthritis: Research Progress on the Combination of Acupuncture and Diclofenac Sodium

Li,

Zhang,

Xie

et al. 2023

IJPS

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Short Communication Li et al.: Research Progress on Treatment of Knee OsteoarthritisKnee osteoarthritis is a common chronic joint disease, and although conventional western medical treatments are effective, they also have certain limitations. Therefore, the integration of traditional Chinese medicine and western medicine has attracted attention as a potential treatment approach. Acupuncture, as a traditional Chinese medicine therapy with a long history, can alleviate pain and improve function by regulating the nervous and immune systems. Diclofenac sodium can reduce inflammation and relieve pain. The combined application of traditional Chinese medicine and western medicine can leverage the complementary advantages of both approaches, achieving better treatment outcomes. Although existing research supports the effectiveness of acupuncture combined with diclofenac sodium in the treatment of knee osteoarthritis, further large-scale and rigorously designed clinical studies are needed to validate its long-term efficacy and safety. The comprehensive evaluation of the combined therapy's effectiveness for knee osteoarthritis includes clinical efficacy, pain relief, functional improvement, enhancement of quality of life and safety. With the continuous progress of scientific research, this therapy is expected to become a more comprehensive and individualized treatment option, improving patients' quality of life and treatment outcomes.

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Study on the relation between tissues pathologies and traditional chinese medicine syndromes in knee osteoarthritis: Medical image diagnostics by preoperative X-ray and surgical arthroscopy

Abstract: For knee osteoarthritis, different syndromes of traditional Chinese medicine presents different tissues pathological changes at the knee joint under arthroscopy, which will provide objective basis for the diagnosis of this medical condition.

Cited by 6 publications

References 24 publications

Relationship Between Conventional Medicine Chapters in ICD-10 and Kampo Pattern Diagnosis: A Cross-Sectional Study

Relationship Between Conventional Medicine Chapters in ICD-10 and Kampo Pattern Diagnosis: A Cross-Sectional Study

BushenHuoxue formula promotes osteogenic differentiation via affecting Hedgehog signaling pathway in bone marrow stem cells to improve osteoporosis symptoms

Integration of Traditional Chinese Medicine and Western Medicine in the Treatment of Knee Osteoarthritis: Research Progress on the Combination of Acupuncture and Diclofenac Sodium

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