Study on the Role of Vitamin D in Systemic Lupus Erythematosus

Abstract

Vitamin D is a hormone precursor with multiple biological effects. It binds to vitamin D receptors on target cells. It is an important participant in the metabolism of calcium and phosphorus in vivo. It is closely related to cell cycle, cell proliferation, differentiation, apoptosis, signal transduction and immune regulation. Its role in the treatment of infection, tumor and even immune diseases has been gradually recognized and studied. Patients with systemic lupus erythematosus generally have decreased levels of active vitamin D, and low levels of vitamin D are associated with disease occurrence, disease activity and complications. In the past ten years, a large number of studies have been carried out on it globally to explore the role of vitamin D in the occurrence and development of systemic lupus erythematosus. This paper summarizes its recent research progress.

Screening of potential biomarkers of system lupus erythematosus based on WGCNA and machine learning algorithms

“…Studies have shown that patients with SLE have elevated serum IFN-α levels, which correlate with disease activity and severity, [40] and biologics targeting type I IFN bring new possibilities for the treatment of SLE. [41] Early studies have found that the ability of macrophages to clear apoptotic cell debris in SLE patients is defective, [42] and recent studies have shown that abnormal activation or interference in the coordination of immune response between monocytes and macrophages will lead to and aggravate immune dysregulation. [43] Neutrophils are involved in the process of inflammation and infection and are an important component of the innate immune system.…”