Study on the toxic effects of sodium pentachlorophenol (PCP–Na) on razor clam (Sinonovacula constricta)

Qi, Ruicheng; Xiao, Guoqiang; Miao, Jingjing; Zhou, Yong; Li, Zeyuan; He, Zhiheng; Zhang, Ning; Song, Aimin; Pan, Luqing

doi:10.1016/j.marenvres.2022.105845

Cited by 4 publications

(2 citation statements)

References 59 publications

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“…[50,51] After chlorfenapyr poisoning, high-energy oxygen-consuming organs are injured, and respiratory circulatory failure occurs in severe cases, [52] similar to the poisoning of sodium pentachlorophenol, a mitochondrial phosphoric acid decoupling poison. [53] Patients with pesticide poisoning can be diagnosed and the poison itself can be identifi ed based on the characteristic clinical manifestations.…”

Section: Diagnosismentioning

confidence: 99%

Chlorfenapyr poisoning: mechanisms, clinical presentations, and treatment strategies

Cheng,

Chen,

Wang

et al. 2024

World Journal of Emergency Medicine

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BACKGROUND: Chlorfenapyr is used to kill insects that are resistant to organophosphorus insecticides. Chlorfenapyr poisoning has a high mortality rate and is difficult to treat. This article aims to review the mechanisms, clinical presentations, and treatment strategies for chlorfenapyr poisoning. DATA RESOURCES:We conducted a review of the literature using PubMed, Web of Science, and SpringerLink from their beginnings to the end of October 2023. The inclusion criteria were systematic reviews, clinical guidelines, retrospective studies, and case reports on chlorfenapyr poisoning that focused on its mechanisms, clinical presentations, and treatment strategies. The references in the included studies were also examined to identify additional sources. RESULTS:We included 57 studies in this review. Chlorfenapyr can be degraded into tralopyril, which is more toxic and reduces energy production by inhibiting the conversion of adenosine diphosphate to adenosine triphosphate. High fever and altered mental status are characteristic clinical presentations of chlorfenapyr poisoning. Once it occurs, respiratory failure occurs immediately, ultimately leading to cardiac arrest and death. Chlorfenapyr poisoning is diffi cult to treat, and there is no specifi c antidote.CONCLUSION: Chlorfenapyr is a new pyrrole pesticide. Although it has been identified as a moderately toxic pesticide by the World Health Organization (WHO), the mortality rate of poisoned patients is extremely high. There is no specifi c antidote for chlorfenapyr poisoning. Therefore, based on the literature review, future eff orts to explore rapid and eff ective detoxifi cation methods, reconstitute intracellular oxidative phosphorylation couplings, identify early biomarkers of chlorfenapyr poisoning, and block the conversion of chlorfenapyr to tralopyril may be helpful for emergency physicians in the diagnosis and treatment of this disease.

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Section: Diagnosismentioning

confidence: 99%

Chlorfenapyr poisoning: mechanisms, clinical presentations, and treatment strategies

Cheng,

Chen,

Wang

et al. 2024

World Journal of Emergency Medicine

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“…All types of seafood showed significantly lower EDIs in adults compared to children, and the EDI of shellfish was significantly higher than that of fish, crab, and shrimp among the residents. In a toxicity study of razor clams, Qi et al [42] noted that PCP-Na readily bioaccumulates in razor clams due to long-term exposure experiments. This finding indicates that shellfish are highly exposed to enrichment.…”

Section: Health Risk Assessmentmentioning

confidence: 99%

Determination of Pentachlorophenol in Seafood Samples from Zhejiang Province Using Pass-Through SPE-UPLC-MS/MS: Occurrence and Human Dietary Exposure Risk

Yan,

Zhao,

Yan

et al. 2023

Molecules

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Pentachlorophenol (PCP) has attracted wide attention due to its high toxicity, persistence, and bioaccumulation. In this study, a sensitive UPLC-MS/MS method for the determination of PCP in seafood samples was developed and validated. The samples were ultrasonic extracted with acetonitrile containing 1% acetic acid-acetonitrile and followed by using a pass-through solid-phase extraction (SPE) cleanup on Captiva EMR-Lipid cartridges. The linearity of this method ranged from 1 to 1000 μg/L, with regression coefficients of >0.99. The detection limit and quantitation limit were 0.5 μg/kg and 1.0 μg/kg, respectively. The recoveries in different types of seafood samples ranged from 86.4% to 102.5%, and the intra-day and inter-day relative standard deviations (RSDs) were 3.7% to 11.2% and 2.9% to 12.1%, respectively (n = 6). Finally, the method has been successfully utilized for the screening of PCP in 760 seafood samples from Zhejiang Province. PCP was detected in 5.8% of all seafood samples, with the largest portion of detections found in shellfish, accounting for approximately 60% of the total. The average concentrations detected ranged from 1.08 to 21.49 μg/kg. The non-carcinogenic risk indices for adults and children who consume PCP ranged from 10−4 to 10−3 magnitudes. All of these indices stayed significantly below 1, implying that the health risk from PCP in marine organisms to humans is minimal.

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Toxicity assessment and detoxification metabolism of sodium pentachlorophenol (PCP-Na) on marine economic species: a case study of Moerella iridescens and Exopalaemon carinicauda

Qi,

Xiao,

Miao

et al. 2023

Environ Sci Pollut Res

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Study on the toxic effects of sodium pentachlorophenol (PCP–Na) on razor clam (Sinonovacula constricta)

Cited by 4 publications

References 59 publications

Chlorfenapyr poisoning: mechanisms, clinical presentations, and treatment strategies

Chlorfenapyr poisoning: mechanisms, clinical presentations, and treatment strategies

Determination of Pentachlorophenol in Seafood Samples from Zhejiang Province Using Pass-Through SPE-UPLC-MS/MS: Occurrence and Human Dietary Exposure Risk

Toxicity assessment and detoxification metabolism of sodium pentachlorophenol (PCP-Na) on marine economic species: a case study of Moerella iridescens and Exopalaemon carinicauda

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