Study on the Wound Healing Activity of TANUVAS Nano-Heal Topical Gel in Clinical Cases of Cattle and Turkey

Rajesh, NV; Iiavarasan, S; Vijayalingam, T.A.

doi:10.20546/ijcmas.2020.907.250

Cited by 2 publications

(2 citation statements)

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“…The interruption of the cellular and anatomical continuity of the tissues that may result from physical, chemical, microbiological, and immunological harm is known as a wound ( Rawat et al, 2012 ; Rajesh et al, 2020 ). Wound healing involves many biochemical events to repair and restore the damaged tissues through antioxidant defenses, epithelization, and remodeling phases ( Cano Sanchez et al, 2018 ; Masson-Meyers et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Enhancement of cell migration and wound healing by nano-herb ointment formulated with biosurfactant, silver nanoparticles and Tridax procumbens

Muthukumar,

Nandini,

Elumalai

et al. 2023

Front. Microbiol.

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IntroductionOintments are generally used as a therapeutic agent for topical medication or transdermal drug delivery, such as wound healing and skin lesions.MethodsIn this study, Tridax procumbens plant extract (0.7 g/mL) was used to prepare herbal-infused oil as the oil phase and gelatin-stabilized silver nanoparticle (G-AgNPs) (0.3 g/mL) as the aqueous phase. To blend the oil and aqueous phases, rhamnolipid biosurfactant with a critical micelle concentration of 55 mg/L from strain Pseudomonas aeruginosa PP4 has been used for herb ointment preparation. The average size of the synthesized G-AgNPs was observed between 10–30 nm and confirmed as spherical-shaped particles by TEM analysis. Subsequently, GC–MS and FTIR characterization are used to confirm herb ointment’s chemical and functional characteristics.ResultsBased on the antibacterial studies, the highest microbial growth inhibition was observed for herb ointment, about 19.5 mm for the pathogen Staphylococcus aureus at the concentration of 100 μg/mL, whereas 15.5 mm was obtained for Escherichia coli, respectively. In addition, the minimum inhibitory concentration (MIC) assay showed negligible bacterial growth at 100 μg/mL for S. aureus and E. coli, respectively. Moreover, the cell viability assay for herb ointment exhibited low cytotoxic activity at higher concentrations (100 μg/mL) in Vero cell lines. In this study, wound scratch assay showed a significant cell migration rate (90 ± 2%) in 3 days of incubation than the control (62 ± 2%).DiscussionAs a result, the biosurfactant-based nano-topical herb ointment revealed a low cytotoxic and higher cell migration capacity. Altogether, these findings highlighted the utility of this herb ointment in therapeutic applications such as wound healing.

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Section: Introductionmentioning

confidence: 99%

Enhancement of cell migration and wound healing by nano-herb ointment formulated with biosurfactant, silver nanoparticles and Tridax procumbens

Muthukumar,

Nandini,

Elumalai

et al. 2023

Front. Microbiol.

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“…Wounds are defined as the cellular and anatomical destruction of tissues that can be caused by chemical, physical, microbiological, thermal, or immunological damage, leading to skin rupture 1 . Wound healing is one of the most complex biological processes, with four overlapping phases: hemostasis, inflammation, proliferative, and maturation.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antibacterial and wound‐healing activities of alcoholic extract of Boswellia carterii, in vitro and in vivo study

Hasson

Jasim

Salman

et al. 2022

J of Cosmetic Dermatology

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Wounds are defined as the cellular and anatomical destruction of tissues that can be caused by chemical, physical, microbiological, thermal, or immunological damage, leading to skin rupture. 1 Wound healing is one of the most complex biological processes, with four overlapping phases: hemostasis, inflammation, proliferative, and maturation. These phases lead to the regeneration of new tissue. In burn injuries, blood coagulation occurs due to damaged capillaries, followed by inflammation. 2,3 The global cost of wound care averaged 2.8 billion dollars in 2014 and is expected to reach 3.5 billion dollars by 2021. 4 A 2018 analysis

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Study on the Wound Healing Activity of TANUVAS Nano-Heal Topical Gel in Clinical Cases of Cattle and Turkey

Cited by 2 publications

References 7 publications

Enhancement of cell migration and wound healing by nano-herb ointment formulated with biosurfactant, silver nanoparticles and Tridax procumbens

Enhancement of cell migration and wound healing by nano-herb ointment formulated with biosurfactant, silver nanoparticles and Tridax procumbens

Evaluation of antibacterial and wound‐healing activities of alcoholic extract of Boswellia carterii, in vitro and in vivo study

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