Abstract:Dry grinding and solvent-drop grinding to prepare the cocrystals of 4-nitropyridine N-oxide (NPNO) and p-aminobenzoic acid (PABA) were investigated in this study. Seven solvents were used during the solvent-drop grinding to accelerate the formation of the cocrystal, and the corresponding implicit solvent models were applied to compute the binding energy between NPNO and PABA via Gaussian 09 to determine the effect of the solvent on solvent-drop grinding. With a combination of Raman spectroscopy and powder Xray… Show more
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