Study on traditional Chinese medicine medication for acne of wind-heat type in lung meridian based on data mining and network pharmacology

Abstract

Acne vulgaris of wind-heat in lung meridian is a common skin disease, and there are many traditional Chinese medicine prescriptions, but the mechanism is still not clear. In this paper, the literature on the treatment of acne due to wind-heat in lung meridian and the prescriptions in the patents were collected and sorted out in the past twenty years. Excel 2019 was used for medication frequency statistics, and IBM SPSS 25.0 was used for clustering analysis to obtain the core formula. Network pharmacology was used to collect the related targets of drugs and diseases, to construct the action network, and to conduct enrichment analysis. A total of 137 prescriptions and 167 drugs were obtained. The core prescriptions were Cortex mori, Folium eriobotryae, Scutellariae radix, Glycyrrhrizae radix, Fructus gardeniae, Radix rehmanniae, and Cortex moutan. The treatment of acne due to wind-heat in lung meridian should begin with clearing heat, purging the lung, cooling blood and detoxicating. The core prescriptions mainly played a role through AKT1, IL6, TP53, TNF, VEGFA, EGF targets and Kaposi's sarcoma-related herpes virus infection, measles, toxoplasmosis, EB virus infection, IL-17, MAPK and other signaling pathways, so as to provide reference for further clinical research.

Application of state-target application of painful arthritis liver and kidney deficiency: A review

“…Jue Yin main reinforcement belongs to the wind, Yang Ming main meat is wet, the work of Bi XieZhi, good at to rheumatism, so can smelting treatment slow weak stubborn bi, heritage turbidity, evil sores of rheumatism. [29] Tufuling is sweet, light, and even, and has the effects of removing toxins, detumescence, dampness, and dredging pulse. [30] It is recorded in "Materia Medica Justice" that Tufuling can clear away heat, eliminate dampness, remove heat, and dredge collateral to eliminate cold and dampness.…”