Study on Unrecognized Peripheral Arterial Disease (PAD) by Ankle/Brachial Index and Arterial Comorbidity in Catania, Sicily, Italy

Signorelli, Salvatore Santo; Anzaldi, Massimiliano; Fiore, Valerio; Catanzaro, Stefano; Simili, Massimo; Torrisi, Benedetto; Neri, Sergio

doi:10.1177/0003319710371614

Cited by 35 publications

(40 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ward et al [18] in the study of 204 patients with symptomatic PAD found that LVEF less than 55% among patients with low ABI is more common than normal ABI. Also in the study by Santo Signorelli et al [19] LVEF < 50% had higher prevalence in patients with ABI ≤ 0.9. Unlike these findings, Thatipelli et al [20] studied 395 patients referred for dobutamin stress echocardiography and ABI determination, and observed that there was no relation between ABI and left ventricle wall motion index score at rest or after stress.…”

Section: Discussionmentioning

confidence: 78%

Relation of Ankle Brachial Index to Left Ventricular Ejection Fraction in Diabetic Patients

Abbasnezhad

2012

J Endocrinol Metab

View full text Add to dashboard Cite

Background: Peripheral arterial disease is associated with an excessive risk for cardiovascular events and mortality. It is usually measured with ankle brachial index (ABI), which is shown to be influenced by left ventricular ejection fraction (LVEF) independent of coronary disease. Diabetics significantly have higher risk for cardiovascular disease. The aim of current study is to evaluate relation of ABI to LVEF in diabetic patients.

show abstract

Section: Discussionmentioning

confidence: 78%

Relation of Ankle Brachial Index to Left Ventricular Ejection Fraction in Diabetic Patients

Abbasnezhad

2012

J Endocrinol Metab

View full text Add to dashboard Cite

show abstract

“…Since then, several groups have confirmed this relationship in different cohorts including elderly patients with ischemic heart disease, diabetics and nondiabetics, and in subjects with atrial fibrillation [8,9,10,11,12]. In addition, few earlier studies reported a relation between LVEF and ABI as a secondary finding [13,14,15].…”

Section: Introductionmentioning

confidence: 88%

The Ankle-Brachial Index Is Related to Left Ventricular Ejection Fraction in Bonnet Macaques

Liu

Bapat²,

Kamran³

et al. 2015

Cardiology

View full text Add to dashboard Cite

Low ankle-brachial index (ABI) is a marker of peripheral arterial disease associated with higher cardiovascular risk. ABI has been found to be influenced by left ventricular ejection fraction (LVEF), but this relation is confounded by atherosclerosis. Objectives: Since nonhuman primates have a low incidence of atherosclerosis, we sought to evaluate the effect of LVEF on ABI in 24 healthy female bonnet macaques (age 83 ± 21 months). Methods: LVEF was determined by echocardiography during anesthesia with ketamine. ABI was determined using automatic blood pressure cuff. Results: Mean LVEF was 73 ± 6%. Mean ABI was 1.03 (range 0.78-1.17) with similar right and left lower limb values (p = 0.78). On univariate analysis, mean ABI was significantly correlated with LVEF (r = 0.58, p = 0.003) but not with age, crown-rump length or weight. Mean LVEF increased in a stepwise manner from lowest to highest ABI tertile (68 ± 6 vs. 73 ± 4 vs. 77 ± 5%, p = 0.008). On ordinal regression and forced multivariate linear analyses, ABI status was independently related to LVEF. Conclusions: ABI is influenced by left ventricular systolic function but not age, height, weight or mass index in bonnet macaques. Left ventricular systolic function should be accounted for when considering ABI measurements.

show abstract

“…However, a limited number of studies have focused on N in severe peripheral arterial disease (PAD) such as critical limb ischemia (21), whereas no study has focused on chronic PAD. PAD is considered a marker of the extent of the atheromatous process and it is known that PAD patients have a high risk of mortality for ischemic events (22)(23)(24)(25). The present study focused on N plasma levels in symptomatic (SyP) and asymptomatic (AsP) PAD patients and compared them to the controls.…”

Section: Introductionmentioning

confidence: 99%

Neopterin: A potential marker in chronic peripheral arterial disease

Signorelli

Anzaldi

Fiore

et al. 2013

Molecular Medicine Reports

Self Cite

View full text Add to dashboard Cite

Abstract. Neopterin is a marker of macrophage activation that has exhibited high plasma levels in atherosclerotic diseases including coronary heart disease and critical limb ischemia. The role of neopterin in chronic peripheral arterial disease (PAD) has yet to be elucidated. In the present study, neopterin (Ν) serum concentrations were analyzed in asymptomatic (AsP) and symptomatic (SyP) patients with PAD as well as controls (C). In total 120 subjects, 40 AsP [ankle brachial index (ABI) ≤0.90], 40 SyP (ABI ≤0.90 plus pain in legs) and 40 controls (ABI >0.9) were enrolled. The results of the present study showed that neopterin plasma levels were statistically different among the groups. These findings demonstrated that activation of N-mediated monocyte-macrophage, was also observed in chronic PAD.

show abstract

Study on Unrecognized Peripheral Arterial Disease (PAD) by Ankle/Brachial Index and Arterial Comorbidity in Catania, Sicily, Italy

Cited by 35 publications

References 33 publications

Relation of Ankle Brachial Index to Left Ventricular Ejection Fraction in Diabetic Patients

Relation of Ankle Brachial Index to Left Ventricular Ejection Fraction in Diabetic Patients

The Ankle-Brachial Index Is Related to Left Ventricular Ejection Fraction in Bonnet Macaques

Neopterin: A potential marker in chronic peripheral arterial disease

Contact Info

Product

Resources

About