Lakes are essential components of the terrestrial water cycle. Their size and quantity reflect natural climate change and anthropogenic activities in time. Lakes on the Inner-Mongolian Plateau (IMP) have experienced significant changes in recent decades, but the current situation remains elusive. In this study, we conducted multi-decadal intensive monitoring of lake area and performed comprehensive variation analysis on the IMP. The study involved pre-processing, lake area extraction, post-processing, and lake area analysis procedures using multi-source satellite images. The results reveal the detailed variation in the lake from various aspects. The temporal analysis indicates that the lake area has undergone two distinct periods of decline followed by subsequent increase, and the variation pattern from January to December was diverse. The spatial analysis suggests that the lake area expanded slightly in the western and southern parts, while the area shrank in the other two. Variations in lakes of different sizes exhibited spatial heterogeneity. To some extent, effective actions have led to lake rehabilitation, but it has not yet reached or surpassed the level of 2000. This study provides a substantial data basis and technological guidance for conducting lacustrine surveys. The results can play important roles in fostering further analyses of the water cycle and the carbon cycle.