This study focuses on wind resistance of high-rise building structures. Firstly, the monitoring results of wind tunnel test are compared with the numerical simulation results based on CFD to verify the feasibility of the CFD numerical method, and the wind pressure coefficients of full-size structures and multi-type high-rise buildings are analyzed with the CFD algorithm. The results show that the monitoring results based on wind tunnel test and CFD simulation are very similar, and the distribution of the overall wind pressure coefficients is basically the same. As seen in top view and elevation view of wind pressure coefficient contours for full-size building structures, the wind pressure coefficient on the windward side and leeward side of a full-size building is relatively small, and the wind pressure coefficient in the incoming wind side is relatively large, which is because of the influence of Reynolds Number Effect in the area of the incoming wind side, which results in the relatively greater negative pressure on the lateral side of the building. The contour distribution of wind pressure coefficients for different types of buildings is generally similar, indicating that the shape of buildings has basically no effect on the distribution of wind pressure coefficients. This study establishes static pressure field fitting curves for the windward, crosswind, upwind, and leeward directions. The "static pressure corridor" can accurately determine the zero pressure position, and long-term monitoring at the point with zero pressure can achieve the best test results.