Study protocol: Language profile in mild cognitive impairment: A prospective study

Khatoonabadi, Ahmad Reza; Masumi, Jafar

doi:10.47176/mjiri.33.53

Cited by 2 publications

(3 citation statements)

References 22 publications

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“…Something important to note here is that the COSMA language games refer only to picture naming and do not test or measure verbal, speaking and communication abilities. This is in alignment with literature showing that language impairment in individuals with MCI is primarily present at the semantic level of processing, which is the meaning of words, and at the syntactic processing, which is the structure of phrases and the association of words to each other within phrases and remains partially unaffected [63].…”

Section: Discussionsupporting

confidence: 90%

“…The study has established the efficacy of COSMA in MCI patients by showing improvement in motor skills and sustained attention within 4 weeks' time of using the application. There are numerous applications in the market focusing on general cognition claiming cognitive improvements, which have no evidence of practical and social benefits to the patients [63]. This is how COSMA differs from the crowded market of cognitive applications, because it has been designed both practically and scientifically for people with cognitive impairments addressing their symptoms and trying to achieve the practical benefits of cognitive improvements in daily life.…”

Section: Discussionmentioning

confidence: 99%

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Attention and Motor skill improvements in Mild Cognitive Impairment patients using COSMA Application

Christogianni

Bojan²,

Mukaetova‐Ladinska³

et al. 2022

IJSG

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Serious games have grown rapidly to provide cognitive stimulation for people with cognitive impairment. In this endeavour, we have created the COSMA games. In this two-arm study with patients with mild cognitive impairment (MCI), we investigated information processing speed and cognitive skills with 28 days of use of COSMA games, a brain stimulation gaming platform. We measured reaction times during neuropsychological assessment with the Cambridge Neuropsychological Test Automated Battery and the COSMA games. Results showed that people with MCI who played COSMA for 28 days at home were faster in 48% of the COSMA games and the Control group which played only during the laboratory visits was faster in 20% of the COSMA games at the end of the study. Overall, these outcomes showed evidence that motor skill practice and learning retention are possible in people with MCI and that these skills are still able to improve with the regular practice of the COSMA games.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Attention and Motor skill improvements in Mild Cognitive Impairment patients using COSMA Application

Christogianni

Bojan²,

Mukaetova‐Ladinska³

et al. 2022

IJSG

View full text Add to dashboard Cite

show abstract

“…In this study, the median course of disease in the AD-D group (36.00 months) was longer than that in the AD-MCI group (24.00 months), with p -value was close to 0.05, demonstrating that AD was a continuous process, and MCI was the early stage of the disease (Bondi et al, 2017 ). It was previously found that language dysfunction happened at the primary stage of AD and developed over time (Khatoonabadi and Masumi, 2019 ). As the disease progressed from MCI to dementia, a continuous decline in language was observed in patients with AD (Szatloczki et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

The Influence of 24-h Ambulatory Blood Pressure on Cognitive Function and Neuropathological Biomarker in Patients With Alzheimer's Disease

Wang

Lian

et al. 2022

Front. Aging Neurosci.

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PurposeThis study aimed to investigate the influence of 24-h ambulatory blood pressure (BP) on cognitive function and neuropathological biomarkers in patients with Alzheimer's disease (AD) at the stages of mild cognitive impairment (MCI) and dementia.MethodsThe patients with AD were divided into the MCI (AD-MCI) group and the dementia (AD-D) group. Notably, 24-h BP variables, including BP level, coefficient of variation (CV) of BP, and pulse pressure, were collected and compared between the two groups. The correlations between 24-h BP variables and the scores of cognitive domains were analyzed. The independent influencing factors of cognitive domains of patients with AD were investigated. The levels of neuropathological biomarkers of AD, including β amyloid (Aβ)1−42, phosphorylated tau (P-tau), and total tau (T-tau), in cerebrospinal fluid (CSF) were measured and compared between the two groups, and the correlations between 24-h BP variables and the levels of neuropathological biomarkers of AD were analyzed.ResultsDaytime CV of systolic BP (SBP) was significantly increased in the AD-D group compared to that in the AD-MCI group. The 24-h and daytime CV of SBP and ambulatory pulse pressure were significantly and negatively correlated with memory score. The average 24-h and average daytime SBP level and CV of SBP, daytime CV of diastolic BP (DBP), and 24-h, daytime, and night-time ambulatory pulse pressure were significantly and negatively correlated with language score. The average 24-h SBP level, daytime CV of SBP, and 24-h, daytime, and night-time ambulatory pulse pressure were significantly and negatively correlated with attention score. Further analysis indicated that daytime CV of SBP as well as age and course of disease were the independent influencing factors of language. Age was also the independent influencing factor of memory and attention of patients with AD. T-tau level in CSF in the AD-D group was significantly higher than that in the AD-MCI group, but the levels of Aβ1−42, P-tau, and T-tau in CSF were not correlated with 24-h ambulatory BP variables.ConclusionDaytime CV of SBP was the independent influencing factor of language in patients with AD. The AD-D patients had significantly severe neurodegeneration than AD-MCI patients, which was, however, not through the influence of 24-h ambulatory BP variables on neuropathological biomarkers of AD.

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Study protocol: Language profile in mild cognitive impairment: A prospective study

Cited by 2 publications

References 22 publications

Attention and Motor skill improvements in Mild Cognitive Impairment patients using COSMA Application

Attention and Motor skill improvements in Mild Cognitive Impairment patients using COSMA Application

The Influence of 24-h Ambulatory Blood Pressure on Cognitive Function and Neuropathological Biomarker in Patients With Alzheimer's Disease

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