Study Regarding the Inhibition of Acetylcholinesterase by Isopropyl 4-Nitrophenyl Methylphosphonate

Abstract

At present, many scientific institutions around the world are interested in the synthesis and improvement of new antidotes against Chemical Warfare Agents (CWAs), especially nerve agents, because of the continuous threat of the nerve agent misuse by terrorists. Few studies have been published concerning the reactivity of CWAs due to the danger of conducting such experiments, the limited laboratory supply of CWAs and the classified nature of the materials. The inherent toxicity and limited laboratory supply of CWAs has led to the development and study of safer compounds that simulate the chemistry and the reactivity of CWAs. Antidotes as Acetylcholinesterase (AChE) reactivators containing oxime groups have been demonstrated to be effective for the breakdown of nerve agents and/or their simulants. The study proposes a simulant for sarin, for experimental