Study the Antifungal Activity of ZnS:Mn Nanoparticles Against Some Isolated Pathogenic Fungi

Dheeb, Batol Imran; Al-dujayli, Sundus M. A.; Ibrahim, Isam M.; Abbas, Qayes A.; Ali, Ahmed H.; Ramizy, Asmiet; Eisa, M. H.; Aljameel, A.I.; Ali, Iftikhar; Khashman, Basim Mohammed; Hussain, Anaam Fuad

doi:10.1088/1742-6596/1178/1/012008

Cited by 13 publications

(8 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These changes can be explained by pharmacological sensitivity with the time, the ability of yeast to tolerate the toxic effects of antimicrobial resistance and its ability to develop some resistance mechanisms. The differences in the results of the current study with the results of other studies in developed countries based on the environmental location and excessive intake of antimicrobial agents may explain the transmission of genetic resistance between resistant isolates to sensitive isolates Due to unhealthy and personal hygiene practices, including the introduction of sewage into drinking water, leading to the transmission of resistance genes [33,35].…”

Section: Comparison Of Isolates Isolated From Respiratory Tractcontrasting

confidence: 59%

Studying the candida resistance and sensitivity for some antifungals

Hussein¹,

Dheeb²,

Hamada³

2019

JoBRC

View full text Add to dashboard Cite

Back ground: The current study included 150 samples from patients with Candida from a hospital of Medical City / education labs - Baghdad, and ranged in age from (10 – 65(years for both sexes, all isolates taken from different sources (Lower respiratory tract, Urine, Skin, Vaginal and Oral thrux), where the number of males (55(as a percentage (37%) while the number of females (95) as a percentage (63%). The objective: The objectives of this study are studying resistance and sensitivity of candida spp to some antifungals. Material and methods: All the required material which used for the study, and the direct examination was conducted using potassium hydroxide KOH 10%, As well as microscopic examination and laboratory transplantation for all samples, for the purpose of investigating the candidiasis. Also Vitek System examination was conducted on all positive samples for microscopy and laboratory culturing; and so to be diagnosed on the species level, and this study included using (3) anti-fungal equipped from Himedia (India), an (Fluconazole, Clotrimazole and Nystatin), anti-fungal used by standard disk Diffusion to know the resistance of Candida and its sensitivity toward used anti-fungal. The results: The results of direct examination were vaginal swab (50), Sputum (28), Oral swab (34), Urine (21) and Skin swab (17). Conclusion: Candidiasis was more common in female patients as well as from medical units, where the rate of infection in females more than in males, Candida species were identified by the manual and automated methods and we found that the automated method by using VITEK2 YST Card was the best for species identification.

show abstract

Section: Comparison Of Isolates Isolated From Respiratory Tractcontrasting

confidence: 59%

Studying the candida resistance and sensitivity for some antifungals

Hussein¹,

Dheeb²,

Hamada³

2019

JoBRC

View full text Add to dashboard Cite

show abstract

“…demonstrated resistance to commercially available antimicrobial agents at an increasing rate and has become a global threat especially in developing countries. To obviate this, nanoparticles were recently used which provide a new strategy for the development of new antimicrobial agents [2,[19][20][21][22]. Among noble metals, silver shows disinfecting, antimicrobial properties and tremendous medicinal value [7,23].…”

mentioning

confidence: 99%

The synergistic effect of biosynthesized silver nanoparticles from a combined extract of parsley, corn silk, and gum arabic: in vivo antioxidant, anti-inflammatory and antimicrobial activities

Helmy

El-Shazly

Seleem

et al. 2020

Mater. Res. Express

View full text Add to dashboard Cite

Microbial resistance, oxidative stress, and inflammatory conditions are among the leading causes of death worldwide. In the current work, silver nanoparticles (AgNPs) were biosynthesized using the aqueous extracts of parsley, corn silk (CS), gum Arabic (GA) or combination of the three extracts. The formed nanoparticles were characterized using three techniques including transmission electron microscopy (TEM), UV-visible spectrophotometer and Fourier-transform infrared spectroscopy (FTIR). The antioxidant, anti-inflammatory, and antimicrobial activities were tested for the formed nanoparticles, the aqueous extracts of each of the three plants and their combination. Oxidative stress was induced by alloxan which promoted the development of diabetes mellitus in rats. Inflammation was induced by injecting carrageenan in rats' paws. Pathogenic microorganisms causing serious urinary tract infection (UTI) were selected for the antimicrobial assay. All aqueous extracts and the biosynthesized AgNPs showed variable degrees of antioxidant, anti-inflammatory and antimicrobial activities, however, the AgNPs biosynthesized by the combination of the three aqueous extracts was the most effective one. LC/MS was done to identify the compounds present in the crude extracts that may be responsible for the observed biological activities. LC/MS resulted in the identification of 13 compounds. Docking experiments on COX-1 (cyclooxygenase-1) and COX-2 (cyclooxygenase-2) were performed to determine the compounds responsible for the antiinflammatory activity of the extracts. The results showed that silver nanoparticles synthesized by the combination of the three aqueous extracts are considered promising candidates for the development of antioxidant, anti-inflammatory and antimicrobial agents. photochemical [10], electrochemical [7, 11], reverse micelle [12], thermal decomposition [13], radiation [7,14] and microwave-assisted [7] methods. Most of these methods require the use of hazardous chemicals and high energy for the preparation of nanoparticles. Biological synthesis of nanoparticles involves the use of natural materials such as plants, bacteria, fungi [1,5,15]. The use of plants for the synthesis of nanoparticles have an advantage over other biological methods as it does not involve the use of cell culture, and does not need longer incubation time required for the reduction of metal ions [16,17]. Plants are known to contain various secondary metabolites such as alkaloids, terpenoids, flavonoids and tannins which provide suitable reducing and surface agents for the nanoparticle synthesis and stabilization. Biopolymers such as cellulose, chitosan, alginate, dextran and tree gums are another family of natural sources which were used for the reduction and stabilization of nanoparticles [17,18].Recently, pathogenic bacteria and fungi such as Staphylococci spp., Enterococci spp., Klebsiella pneumoniae, and Pseudomonas spp. demonstrated resistance to commercially available antimicrobial agents at an increasing rate and has become a global thr...

show abstract

“…Fatemeh in 2016 examined that designed ZnO nanofluids are effective in reducing in-vitro fungal growth on dermal (ringworm), mucosal (thrush), and vaginal infections samples [41]. Recently synthesized nanostructures of zinc, manganese, and thioacetamide have been found to possess antifungal activity against pathogenic fungal species [42]. In recent studies, ZnO nanoparticles were synthesized that exhibited antifungal activity [43][44][45][46][47].…”

Section: Zinc Nanostructures and Their Hybridsmentioning

confidence: 99%

Anti-fungal therapy via incorporation of nanostructures: A systematic review for new dimensions

Younus¹,

Khan²,

Maqbool³

et al. 2022

Phys. Scr.

View full text Add to dashboard Cite

Background: Fungal infections are one of the most prevailing worldwide public health issues. Despite the commercially available antifungal drugs, side effects associated with these agents and resistance may lead to the development of antifungal drugs by using advanced technology. Main body of the abstract: In the current era, nanotechnology is one of the most predominant techniques with massive advantages in the field of medicines and medical sciences. In the last two decades, various nanostructures were developed based on metals, plants, and microorganisms. The aim of the review is to discuss all original researches and to review articles of the last two decades, including earlier and recent development in different types of nanostructures as an antifungal therapy. Published papers in the English language were searched and reviewed from the online databases from January 2007 till May 2021. The search engines included were PubMed, Google, Google scholar, and Sciencedirect. In all the databases, the keywords “fungi”, “antifungal”, “nanomaterials”, “nanostructures” and “nanotechnology” were used for literature search. Short conclusion: The innovative nanostructures are vital for the treatment of different strains of fungal infections i.e. from minor nail infections to major systemic fungal infections. Additionally, nanostructures also enhance the efficacy, solubility, penetration, and drug release to the targeted site of conventional antifungal agents.

show abstract

Study the Antifungal Activity of ZnS:Mn Nanoparticles Against Some Isolated Pathogenic Fungi

Cited by 13 publications

References 26 publications

Studying the candida resistance and sensitivity for some antifungals

Studying the candida resistance and sensitivity for some antifungals

The synergistic effect of biosynthesized silver nanoparticles from a combined extract of parsley, corn silk, and gum arabic: in vivo antioxidant, anti-inflammatory and antimicrobial activities

Anti-fungal therapy via incorporation of nanostructures: A systematic review for new dimensions

Contact Info

Product

Resources

About