Study the Biological and Biochemical Effects of Some Dried Fruits on Acute Renal Failure in Rats

Abstract

Golden berry and sweet cherry are known as nutritious fruit and herbal medicine for healthpromoting properties. This study was conducted to investigate the effect of golden berry and sweet cherry on acute renal failure in rats induced by glycerol.Thirty six male albino adult rats (150±10 g.) were used, divided into two main groups; one (6 rats each) was used as a negative control group, while the other group of rats were injected intramuscularly with glycerol 10 ml/kg BW (50% v/v in sterile saline 0.9 %) to induce acute renal failure. The second main group was divided into 5 equal subgroups ; one used as a positive control and the other four groups were fed on supplemented diet (5 % and 10 %) of each of dried golden berry and sweet cherry.Biological evaluation, liver enzymes, kidney functions, Na, K and serum antioxidant markers were estimated at the end of the experiment. The results indicated that kidney and liver functions were restored significantly in groups of rats which received golden berry and sweet cherry 10%, followed by golden berry and sweet cherry 5 % as compared to the positive control group. Glycerol rats group showed significant decrease in serum proteins and serum electrolytes. On the other hand, all supplemented groups with golden berry and sweet cherry showed a gradual significant increase in the mentioned parameters. Therefore, this study reveals the benefits of golden berry and sweet cherry in experimental animals with kidney and liver disease. Key words: Acute renal failureglycerolgolden berry and sweet cherry. total phenolic content (TPC) has been reported both in sweet and sour cherries(Serradilla et al., 2016). Glycerol injection caused histopathological changes such as renal tubular injury and renal tubular myoglobin deposition. Levels of N.-(hexanoyl) lysine-modified, 4-hydroxyl-2 nonenalmodified and nitrotyrosine-modified proteins in rat kidneys were unaltered at 1 hour after glycerol injection induced acute kidney injury (Akina et al., 2016). Objective of the study This study was carried out to investigate the effect of golden berry and sweet cherry on acute renal failure induced by glycerol in rats. Materials and Methods Materials: Golden berry and sweet cherry were obtained from local market, Tanta City El-Gharbia Governorate., Egypt. Glycerol, Casein, minerals, vitamins, and cellulose were obtained from El-Faroniah (Chemicals Company), Tanta, Egypt. Thirty six male albino rats (Sprague Dawely) Strain) were purchased from the laboratory animal house of faculty of science, Tanta University, Egypt. Methods: Dehydration: Golden berry and sweet cherry were picked gently washed, carefully drained, dried in the oven at 50°C for 24 hr., crushed and stored in labeled polyethylene bags until analysis. Nutritional Characteristics Chemical Composition: Golden berry and sweet cherry were chemically analyzed for moisture, fat, crude protein, crude fiber, and ash, according to methods of (A.O.A.C., 2000). Total carbohydrates were estimated by difference. Whereas, the energy was calculated by the...

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