Study the Effect of Allicin Nanoparticles In Thyroid Activity in Hyperthyroidism Experimental Induced Female Rats

Abstract

The present study has been designed to investigate impact of allicin nanoparticles on female rats with induction of the hyperthyroidism. Fifty mature female rats (aged 90 days and weighted 150±10 g) have been randomly assigned to 5 equal groups (10 each),control (C) group , T1,T2,T3 and T4 groups were drenched with thyroxine (300mg/kg of B.W for 28 days ) for hyperthyroidism induction, T2 was drenched with methimazole (2.5 mg/kg of B.W for 30 days), T3 was drenched with allicin nanoparticles (50 mg/kg of B.W for 30 days) and T4 was drenched with methimazole and allicin nanoparticles for 30 days. The results showed a significant increase in thyroid hormones (triiodothyronine (T 3 ) and thyroxine (T 4 )) and iodine levels in T1 as compared with control group while decreasing these parameters in T2, T3 and T4 as compared with T1. Thyroid stimulating hormone (TSH) decrease in T1 while increase in T2,T3 and T4. The histopathological changes in thyroid gland showed normal thyroid tissue in control group whereas, in T1 thyroid tissue showed normal with dilated thyroid follicles and it contains colloid in their lumen. T2 showed small in thyroid follicles size and empty for colloid with hyperplasia of epithelial cells. T3 showed high dilation of thyroid follicles with large amount of colloid . we can conclud that allicin nanoparticles at dose 50 mg/kg of B.W appears to enhance its bioavailability and effectiveness combating oxidative stress associated with hyperthyroidism.