Study the effect of dip in reaction temperature on thermal and electrical properties of ZnO nanoparticles

Koutu, Vaibhav; Subohi, Oroosa; Shastri, Lokesh A.; Malik, М. M.

doi:10.1016/j.apt.2018.05.012

Cited by 13 publications

(6 citation statements)

References 24 publications

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“…The aforementioned XRD pattern data demonstrated the progression of the JB samples toward nanosize with a changed crystal structure, followed by the advancement of the incineration process. These variations in the XRD patterns of ZnO nanoparticles correspond closely to those obtained using hydrothermal and co-precipitation techniques, indicating a shift in size and crystal lattice. − There were no other peaks found in JBs’ XRD spectra that might reflect different phases of ZnO or contaminants (Figure ). Thus, the XRD data suggested that the synthesized JB samples were of high purity.…”

Section: Resultssupporting

confidence: 65%

“…These variations in the XRD patterns of ZnO nanoparticles correspond closely to those obtained using hydrothermal and co-precipitation techniques, indicating a shift in size and crystal lattice. 44 − 48 There were no other peaks found in JBs’ XRD spectra that might reflect different phases of ZnO or contaminants ( Figure 1 ). Thus, the XRD data suggested that the synthesized JB samples were of high purity.…”

Section: Resultsmentioning

confidence: 99%

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Investigating the Role of Classical Ayurveda-Based Incineration Process on the Synthesis of Zinc Oxide Based Jasada Bhasma Nanoparticles and Zn²⁺ Bioavailability

Balkrishna

Sharma

et al. 2023

ACS Omega

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Jasada bhasma (JB) is a zinc oxide-based Indian traditional Ayurveda-based herbo-metallic nanoparticle used for the treatment of zinc (Zn) deficiency and autoimmune and inflammatory disorders. JB is made by following the Ayurveda-based guidelines using zinc oxide (ZnO) as a raw material and going through 17 cycles of the high-temperature incineration and trituration process known as “Ma̅raṇa” in the presence of herbal decoctions prepared from the leaves ofAzadirachta indica andAloe vera gel. These cycles improve the purity of the parent material and transform its physicochemical properties, converting it into nanoparticles. However, there still exists a knowledge gap regarding the role of incineration in the physicochemical transformation of the Zn raw material into JB nanoparticles and the biological interaction of the final product. In the present study, the JB samples obtained during different Ma̅raṇa cycles were carefully studied for their physicochemical transformation using analytical methods such as powdered X-ray diffraction (XRD), small-angle X-ray scattering (SAXS), field emission scanning electron microscopy (FESEM), energy-dispersive X-ray spectroscopy, Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, and dynamic light scattering (DLS). According to the XRD results, the Zn and oxygen molecules in hexagonal ZnO wurtzite crystals gradually realigned as a result of repeated heat treatments that caused lattice tension and crystal size reduction from 53.14 to 42.40 nm. A morphological transition from 1.5 μm rod shape to 31 nm in the JB particles can be seen using FESEM and SAXS analyses. The existence of 10 nm-sized nanoparticles in the finished product was confirmed by HRTEM. The presence of ZnO was confirmed in all samples by FTIR and Raman spectroscopies. Cell viability analysis showed an inhibitory concentration 50% of >1000 μg/mL for JB nanoparticles, revealing no adverse effects in human colon Caco-2 cells. A dose-dependent uptake and intracellular accumulation of JB nanoparticles were observed in Caco-2 cells using inductively coupled plasma-based mass spectroscopy (ICP–MS). Bioavailability of Zn2+ ions (6% w/w) through JB dissolution in acidic pH 4.0 was observed, representing the stomach and intracellular lysosomal physiological conditions. Therefore, the study showed that the repeated incineration cycles produced biocompatible JB nanoparticles through the physicochemical transformation at molecular levels capable of delivering bioavailable Zn2+ ions under physiological conditions. In conclusion, the medicinal properties of JB nanoparticles described in Ayurveda were found to originate from their small size and dissolution properties, formed through the classical incineration-based synthesis process.

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Section: Resultssupporting

confidence: 65%

Section: Resultsmentioning

confidence: 99%

Investigating the Role of Classical Ayurveda-Based Incineration Process on the Synthesis of Zinc Oxide Based Jasada Bhasma Nanoparticles and Zn²⁺ Bioavailability

Balkrishna

Sharma

et al. 2023

ACS Omega

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“…Also, it is associated with the frequent dosing of drugs in regular time intervals, failing to which reduces the efficacy of anticancer drugs. This drawback can be eliminated or greatly reduced by adopting a sustained drug release mechanism, the main objective of which is to improve the stability, bioavailability, and pharmacokinetics of anticancer drugs [ 71 , 72 ]. Sustained drug release can be defined as any drug or dosage form modification that prolongs the therapeutic activity of the drug [ 73 ].…”

Section: Reviewmentioning

confidence: 99%

Nanotechnology in Lung Cancer Therapeutics: A Narrative Review

Koutu¹,

Gupta²,

Das³

et al. 2023

Cureus

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To date, cancer continues to be one of the biggest challenges for medical science. Nanotechnology has enabled us to overcome some of the limitations of conventional treatment in lung cancer therapeutics. Recently, US Food and Drug Administration (FDA) has approved certain nanomedicines for clinical administration against lung cancer. This article presents a narrative review of approved nanomedicines in lung cancer with a special focus on the results of recently concluded and ongoing clinical trials. The limitations associated with using nanomaterials as anti-lung cancer therapeutic agents and the possible mechanisms to overcome these limitations are also discussed.

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“…[ 58–65 ] Though it is now established that the plant extracts meaningfully control the size and energy band of the ZnO NPs, there are only few reports on the dielectric studies of the green‐synthesized ZnO NPs. [ 5,66–70 ]…”

Section: Introductionmentioning

confidence: 99%

Dielectric Property, AC Conductivity, and Electric Modulus Studies of Pristine and Green‐Synthesized ZnO Nanoparticles

Sarkar,

Kundu,

Bhattacharjee

2024

Physica Status Solidi (a)

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Frequency‐dependent dielectric constant and dielectric loss of pristine and green‐synthesized (using Tabernaemontana divaricata flower extract) ZnO nanoparticles (NPs) are studied at different temperatures. Below 1 kHz frequency and at temperatures above 100 °C, ZnO NPs have giant dielectric constant values (≈3 × 104). At lower frequencies and at/below 100 °C, the nature of temperature dependence of dielectric constant for pristine and green‐synthesized ZnO NPs are reversed, and this anomalous temperature dependence is correlated with the in‐plane and out‐of‐plane thermal expansions of ZnO. A temperature‐dependent poly‐dispersive relaxation mechanism in ZnO has been observed. The electrical conduction mechanism is found to be significantly modulated by the use of flower extract. The electric modulus study suggests similar mechanism of electrical conduction and dielectric polarization followed in these materials. A plausible growth mechanism of the ZnO NPs in presence of the flower extract is explored. Variations in the dielectric constant, dielectric loss, conductivity, and polarization mechanisms of the ZnO NPs are understood as signatures of the capping effect of the phytochemicals present in the flower extract on the crystal growth and formation of grain boundaries.

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Study the effect of dip in reaction temperature on thermal and electrical properties of ZnO nanoparticles

Cited by 13 publications

References 24 publications

Investigating the Role of Classical Ayurveda-Based Incineration Process on the Synthesis of Zinc Oxide Based Jasada Bhasma Nanoparticles and Zn²⁺ Bioavailability

Investigating the Role of Classical Ayurveda-Based Incineration Process on the Synthesis of Zinc Oxide Based Jasada Bhasma Nanoparticles and Zn²⁺ Bioavailability

Nanotechnology in Lung Cancer Therapeutics: A Narrative Review

Dielectric Property, AC Conductivity, and Electric Modulus Studies of Pristine and Green‐Synthesized ZnO Nanoparticles

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Study the effect of dip in reaction temperature on thermal and electrical properties of ZnO nanoparticles

Cited by 13 publications

References 24 publications

Investigating the Role of Classical Ayurveda-Based Incineration Process on the Synthesis of Zinc Oxide Based Jasada Bhasma Nanoparticles and Zn2+ Bioavailability

Investigating the Role of Classical Ayurveda-Based Incineration Process on the Synthesis of Zinc Oxide Based Jasada Bhasma Nanoparticles and Zn2+ Bioavailability

Nanotechnology in Lung Cancer Therapeutics: A Narrative Review

Dielectric Property, AC Conductivity, and Electric Modulus Studies of Pristine and Green‐Synthesized ZnO Nanoparticles

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Product

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Investigating the Role of Classical Ayurveda-Based Incineration Process on the Synthesis of Zinc Oxide Based Jasada Bhasma Nanoparticles and Zn²⁺ Bioavailability

Investigating the Role of Classical Ayurveda-Based Incineration Process on the Synthesis of Zinc Oxide Based Jasada Bhasma Nanoparticles and Zn²⁺ Bioavailability