Study the effect of Metronidazole Drug (MTZ) and Rhuscoriaria (Sumac) on Testicular Tissues and sperms of Male White Mice

Abstract

In this study, thirty adult Swiss male mice weighing with an average weight of twenty seven gram were used. The animals were housed in animal house of the college of Veterinary Medicine/ Tikrit University under normal conditions. The whole animals were divided into three groups each of ten mice, and subdivided into two periods (fourteen and twenty eight days), first group considered as control which were administered with distilled water only. The second group was treated with the metronidazole (MTZ) at a dose of 0.37 mg / mouse /day, the third group were administered with the sumac solution of 0.04 ml / mouse / day. All groups were administered orally. Histological technique was performed to study the effect of MTZ and sumac on the tissues of testis in addition of sperm qualification. The study showed that, the second group of (the two periods) represented the absence of the spermatogonia with the presence of leydig cells in the interstitial tissue. The third group demonstrated a histopathological effect on the testicular tissue such as seminiferous tubules. The study of the effect of MTZ and sumac on the proportion of male sperm showed abnormalities, and the effect of the MTZ showed significant (P≤ 0.01) abnormalities in the confirmation sperms compared with the control group and sumac.

Effect of metronidazole on placental and fetal development in albino rats

“…These authors attributed this effect to the action of metronidazole on the ovarian follicles of the treated females, dismissing a post-fertilization effect since the administration of the drug occurred before mating. Furthermore, studies showed cytotoxicity of this drug in studies about germ cells (El-Nahas and El-Ashmawy, 2004;Rasheed et al 2018), also indicating the possibility of a cytotoxic effect in some released oocytes.…”