Study the Effect of Silymarin and Vitamin C in Skin Aging Induced by UVB Rays on the Mice Skin Redox System

Abstract

Background: Exposure of the skin against occupational hazards is growing every day. Many scientists are trying to identify aspects about the mechanisms of damages done to the skin by them. The skin is the second metabolism organ of the body where redox-dependent metabolic pathways overcome. By considering the UV index, Iranians are at high risk of UVB damage by generation of reactive oxygen species (ROS) that leads to skin aging.Objective: In this study, we discuss the effects of the UVB rays on redox system; evaluate and compare the protective role of Silymarin and Vitamin C against UVB-induced skin aging. Method: MaleBalb/C mice were divided into 6 groups of 6 mices: Silymarin, Vitamin C, Control, UVB exposed, UVB exposed treated with Silymarin and UVB exposed treated with Vitamin C. The inhibitory effect of Silymarin and Vitamin C for skin aging were determined by wrinkle formation, epidermal thickness and dermal inflammation. The anti-photo aging effects of Silymarin and Vitamin C have been assessed by SOD, GSH, GSH_PX and TAC kits. Results: The flake in UVB irradiated groups was significantly different (P<0.05). The mean length of the wrinkle in UVB irradiated group very significantly increased (P<0.01) and the collagen reduction, increased in very high significant different in aged control group (P<0.001). The mean TAC in VitaminC group increased very significantly high. (P <0.0001) Conclusion: The results indicate that the Silymarin and Vitamin C have anti-photo aging effects suggested to use in anti-wrinkle, anti erythematosus, anti-inflammatory topical cosmetics products.

Cosmeceutical Potential of Major Tropical and Subtropical Fruit By-Products for a Sustainable Revalorization

“…As we age, our body produces less collagen and elastin, which plumps our skin and makes it lose its elasticity [ 104 ]. The changes in the skin are among the most visible signs of aging, which include wrinkles, sagging skin, age spots and dryness, and also fat loss, making the skin lose its natural smoothness [ 104 , 105 ]. Moreover, there are other phenomena mainly caused by extrinsic factors which promote skin impairment and tissue damage, or even more hazardous issues at a cellular and genetic level.…”

Amelioration of silymarin against cadmium‐induced toxicity in pregnant rats and their fetuses

“…Silybin is the primary active component of silymarin with antioxidant capabilities to have hepatoprotective effects in human (Federico et al, 2017). Silymarin is safe for both pregnant rats and their developing fetuses, it can cross the placenta and prevent fetal weight loss during gestation due to alcohol use (Ahmadi-Ashtiani et al, 2011). It has been established that silymarin is safe to use throughout gestation and breastfeeding because of its antioxidant activity and its potential to be passed to the fetus via the placenta.…”