Study the levels of Leptin, and Adiponectin with Paraoxonase in Obese Individuals (male & female)

Abstract

Obesity is a well-known risk factor of metabolic complications and cardiovascular disease. Associations between anthropometric measurements and fat distribution and risk factors for cardiovascular disease have been demonstrated in several populations.
 To study the association of various measures of body mass index (BMI), waist circumference (WC), percentage of body fat (%BF), with leptin, Adiponectin, and paraoxonase. To study the association between leptin , adiponectin with Paraoxonase.
 This study conducted from of February 2013 until March 2014, all individuals were randomly recruited from Kirkuk and Tikrit Governorate .Hormonal assay of leptin, adiponectin, Paraoxonase, and glucose. Blood samples collected from 220 individuals, and these samples were divided into three groups according to BMI. Group 1 (Normal Weight group n=80), Group 2 (Over Weight group, n=58), Group 3 (Obese group, n=62) .
 The statistical analysis (students t-test) exhibited significant (P≥ 0.0001)elevation for leptin , paraoxonase, and glucose, while significant decrease in adiponectin in over weight and obese groups compared with normal weight groups.
 The correlation coefficient (r) between Leptin and other parameters were calculated with regression plot showed a negative correlation with adiponectin, and paraoxonase in over weight and obese group. There was a positive correlation between adiponectin with paraoxonase, but a negative correlation with leptin, in over weight and obese group.
 Conclusion: Adiponectin as hormone play an important role in the prevention of hyperlipidemia, and consequently atherosclerosis and its complications while Leptin act as atherosclerotic factors. The results indicated that adiponectin positively associated with paraoxonase while Leptin negatively correlated with paraoxonase.