We show via detailed experimental investigations that the single pulse from Nd:YAG and Nd:Glass lasers (wavelength 1.06 μm, free lasing operation) are suitable for efficient cleaning initial carious lesions (1 - 3 mm in diameter) on tooth enamel. The cleaning is in combination with tooth preparation for final healing procedures – formation of desired hole and antibacterial cleaning. The measured heating of the tooth chamber is in acceptable limits and crack formation is avoided. The investigation includes laser irradiation with single pulses of energy of ~2 to 5 J, energy density of ~50 to 130 J/cm2 and pulse duration of ~500 ns – 2 ms. In further development of the topic, as a second part of this article, we propose algorithm for application of the discussed cleaning.