Study the role of poly(diethyl aminoethyl methacrylate) as a modified and grafted shell for TiO2 and ZnO nanoparticles, application in flutamide delivery

Ensafi, Ali A.; Khoddami, Elaheh; Nabiyan, Afshin; Rezaei, Behzad

doi:10.1016/j.reactfunctpolym.2017.04.016

Cited by 16 publications

(6 citation statements)

References 33 publications

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“…The weight losses observed at lower temperatures are attributed to the decomposition of side chains of polymers while those at higher temperatures are attributed to main-chain degradation. 60 , 61 According to Table 2 , the onset degradation temperature increased 12 °C from cured, unloaded poly(GMA- stat -C13MA) (S-0) to the 4 wt % PTS-reinforced nanocomposite (S-4). Additionally, there was an increase in the maximum decomposition temperatures from 317 and 404 °C to 337 and 421 °C, respectively, indicating an improvement in the thermal stability of the nanocomposites.…”

Section: Results and Discussionmentioning

confidence: 99%

Epoxidized Block and Statistical Copolymers Reinforced by Organophosphorus–Titanium–Silicon Hybrid Nanoparticles: Morphology and Thermal and Mechanical Properties

2021

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Glycidyl methacrylate (GMA) and a mixture of alkyl methacrylates (average chain length of 13 carbons; termed C13MA; derived from vegetable oils) were copolymerized by nitroxide-mediated polymerization to form epoxidized statistical and block copolymers with similar compositions ( F GMA ∼0.8), which were further cross-linked by a bio-based diamine. Hybrid plate-like nanoparticles containing organophosphorus–titanium–silicon (PTS) with an average size of ∼130 nm and high decomposition temperature (485 °C) were synthesized via a hydrothermal reaction to serve as additives to simultaneously enhance the thermal and mechanical properties of the blend. Nanocomposites filled with PTS were prepared at different filler-loading levels (0.5, 2, 4 wt %). Transmission electron microscopy (TEM) of the cured block copolymer displayed reaction-induced macrophase-separated domains. TEM also showed an effective dispersion of PTS hybrids in the matrix without intense agglomeration. Thermogravimetric analysis at different heating rates revealed the activation energy of poly (GMA- stat -C13MA) at maximum decomposition increased from 143.5 to 327.2 kJ mol –1 with 4 wt % PTS. Decomposition temperature and char residue improved 12 °C and ∼7 wt %, respectively, and T g increased 12 °C by adding 4 wt % PTS. Targeting various PTS concentrations enabled tuning of the tensile modulus (up to 75%), tensile strength (up to 46%), and storage modulus in both glassy state (up to 59%) and rubbery plateau regions (up to 88%). Oscillatory frequency sweeps indicated that PTS makes the storage modulus frequency dependent, suggesting that the inclusion of the nanoparticles alters the relaxation of the surrounding matrix polymer.

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Section: Results and Discussionmentioning

confidence: 99%

Epoxidized Block and Statistical Copolymers Reinforced by Organophosphorus–Titanium–Silicon Hybrid Nanoparticles: Morphology and Thermal and Mechanical Properties

2021

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“…To date, a relatively large number of works devoted to modification of TiO 2 nanoparticles with various polymers have been published. The most common method is controlled atom transfer radical polymerization (ATRP) of vinyl monomers involving α-Br-ester groups immobilized on nanoparticle surface [42][43][44][45][46][47][48][49][50][51][52][53][54]. In most cases, this immobilization is preceded by modification of TiO 2 surface with amino groups in the process of treatment of nanoparticles with 3-aminopropyltriethoxysilane [42,[48][49][50][51]53] or dopamine [43].…”

Section: Introductionmentioning

confidence: 99%

“…Then, the obtained nanoparticles are treated with bromoanhydrides of 2-bromopropionic or 2bromo-isobutyric acids [42,43,[48][49][50][51]53], which results in immobilization of ATRP-initiating α-Br-ester groups on nanoparticle surface. In some cases, TiO 2 nanoparticles are immediately treated with 2-Br-isobutyroyl bromide [44].…”

Section: Introductionmentioning

confidence: 99%

“…It should be noted that there are virtually no literature data on modification of TiO 2 nanoparticle surfaces with water-soluble polymers. A small number of published papers report the synthesis of titanium dioxide and zinc oxide nanoparticles modified with poly(N,N-diethylaminoethyl methacrylate), which were used as nanocontainers for anticancer preparations [44]. Titanium dioxide nanoparticles modified with ionized poly(styrene sulfonic acid) were used as ion exchangers for Ag + ; the products were intended for applications as TiO 2 /Ag binary nanocomposite photocatalysts [45] and one of components of proton-conducting membranes [54].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of core-shell titanium dioxide nanoparticles with water-soluble shell of poly(methacrylic acid)

Краснопеева¹,

Melenevskaya²,

Шилова³

et al. 2021

Nanosystems: Phys. Chem. Math.

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“…In this way, inorganic nanomaterials provide a robust framework, while integrated organic components offer functionality. These existing inorganic nanomaterials, such as silica nanoparticles [4,5], TiO 2 nanotubes [6] and ZnO nanoparticles [7], not only conquer the problem of drug delivery, but also improve the therapeutic efficiency of drugs. Silica nanoparticles (SNPs) are considered a carrier of drugs owing to their excellent properties such as large specific surface area, high chemical and mechanical stability, prominent biocompatibility, well-defined surface chemistry and low cytotoxicity [8,9].…”

Section: Introductionmentioning

confidence: 99%

PH-Sensitive, Polymer Functionalized, Nonporous Silica Nanoparticles for Quercetin Controlled Release

Wang

2019

Polymers

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Some pH-sensitive, poly(2-(diethylamino)ethyl methacrylate) (PDEAEMA) grafted silica nanoparticles (SNPs) (SNPs-g-PDEAEMA) were designed and synthesized via surface initiated, metal-free, photoinduced atom transfer radical polymerization (ATRP). The structures of the polymers formed in solution were determined by 1H NMR. The modified nanoparticles were characterized by FT-IR spectroscopy, XPS, GPC, TEM and TGA. The analytical results show that α-bromoisobutyryl bromide (BIBB) (ATRP initiator) had been successfully anchored onto SNPs’ surfaces, and was followed by surface-initiated, metal-free ATRP of 2-(diethylamino)ethyl methacrylate (DEAEMA). The resultant SNPs-g-PDEAEMA were uniform spherical nanoparticles with the particles size of about 22–25 nm, and the graft density of PDEAEMA on SNPs’ surfaces obtained by TGA was 19.98 μmol/m2. Owing to the covalent grafting of pH-sensitive PDEAEMA, SNPs-g-PDEAEMA can dispersed well in acidic aqueous solution, but poorly in neutral and alkaline aqueous solutions, which is conducive to being employed as drug carriers to construct a pH-sensitive controlled drug delivery system. In vitro cytotoxicity evaluation results showed that the cytotoxicity of SNPs-g-PDEAEMA to the L929 cells had completely disappeared on the 3rd day. The loading of quercetin on SNPs-g-PDEAEMA was performed using adsorption process from ethanol solutions, and the dialysis release rate increased sharply when the pH value of phosphate-buffered saline (PBS) decreased from 7.4 to 5.5. All these results indicated that the pH-responsive microcapsules could serve as potential anti-cancer drug carriers.

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Study the role of poly(diethyl aminoethyl methacrylate) as a modified and grafted shell for TiO2 and ZnO nanoparticles, application in flutamide delivery

Cited by 16 publications

References 33 publications

Epoxidized Block and Statistical Copolymers Reinforced by Organophosphorus–Titanium–Silicon Hybrid Nanoparticles: Morphology and Thermal and Mechanical Properties

Epoxidized Block and Statistical Copolymers Reinforced by Organophosphorus–Titanium–Silicon Hybrid Nanoparticles: Morphology and Thermal and Mechanical Properties

Synthesis of core-shell titanium dioxide nanoparticles with water-soluble shell of poly(methacrylic acid)

PH-Sensitive, Polymer Functionalized, Nonporous Silica Nanoparticles for Quercetin Controlled Release

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