Study to assess<i>in vitro</i>antimicrobial activity of nine ear cleaners against 50<i><scp>M</scp>alassezia pachydermatis</i>isolates

Mason, Carly; Steen, Stephen; Paterson, Sue; Cripps, Peter

doi:10.1111/vde.12024

Cited by 16 publications

(24 citation statements)

References 33 publications

(116 reference statements)

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“…With respect to prevention of recurrent Malassezia otitis, while studies in vitro have demonstrated antimicrobial efficacy of ear cleaners, there are only two studies examining topical therapy for prevention of Malassezia otitis. A single study examining dogs with recurrent allergic otitis showed a favourable outcome to a once weekly ear cleaner containing chloroxylenol and cerumenolytics (Epiotic, Virbac Carros, France) and concurrent twice weekly three drops per ear of 0.0584% topical hydrocortisone aceponate solution (Cortavance, VIRBAC SA, Carros, France) (95% chance of remaining free of relapse at day 180) compared with weekly ear cleaner alone (50% chance of remaining infection free at day 180) .…”

Section: Prevention Of Malassezia‐associated Skin Diseases In Dogs Anmentioning

confidence: 99%

Biology, diagnosis and treatment ofMalasseziadermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

Bond

Morris

Guillot

et al. 2020

Veterinary Dermatology

118

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Background -The genus Malassezia is comprised of a group of lipophilic yeasts that have evolved as skin commensals and opportunistic cutaneous pathogens of a variety of mammals and birds.Objectives -The objective of this document is to provide the veterinary community and other interested parties with current information on the ecology, pathophysiology, diagnosis, treatment and prevention of skin diseases associated with Malassezia yeasts in dogs and cats.Methods and material -The authors served as a Guideline Panel (GP) and reviewed the literature available prior to October 2018. The GP prepared a detailed literature review and made recommendations on selected topics. The World Association of Veterinary Dermatology (WAVD) Clinical Consensus Guideline committee provided guidance and oversight for this process. The document was presented at two international meetings of veterinary dermatology societies and one international mycology workshop; it was made available for comment on the WAVD website for a period of six months. Comments were shared with the GP electronically and responses incorporated into the final document.Conclusions and clinical importance -There has been a remarkable expansion of knowledge on Malassezia yeasts and their role in animal disease, particularly since the early 1990's. Malassezia dermatitis in dogs and cats has evolved from a disease of obscurity and controversy on its existence, to now being a routine diagnosis in general veterinary practice. Clinical signs are well recognised and diagnostic approaches are well developed. A range of topical and systemic therapies is known to be effective, especially when predisposing factors are identified and corrected.

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Section: Prevention Of Malassezia‐associated Skin Diseases In Dogs Anmentioning

confidence: 99%

Biology, diagnosis and treatment ofMalasseziadermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

Bond

Morris

Guillot

et al. 2020

Veterinary Dermatology

118

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“…, Mason et al . ). Whilst it is difficult to conclude the exact reason for the extent of in vitro activity of the ear cleaners tested because they varied widely in their ingredients, there are components of many of them with proven antiyeast activity.…”

Section: Topical Therapy To Manage Secondary Causes Of Otitismentioning

confidence: 97%

“…, Mason et al . ). Parachlorometaxylenol (PCMX), a component of many ear cleaners, is also suggested to confer antiyeast activity (Lloyd & Lamport , Reme et al .…”

Section: Topical Therapy To Manage Secondary Causes Of Otitismentioning

confidence: 97%

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Topical ear treatment – options, indications and limitations of current therapy

Paterson

2016

J of Small Animal Practice

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Topical otic products form an integral part of the overall management of otitis externa. With an ever increasing array of ear drops and cleaners to choose from, appropriate selection of therapy can be difficult. The investigation of all cases of otitis externa should consider primary and secondary causes and predisposing and perpetuating factors. This article considers topical therapy under these same broad headings and discusses, through literature review, the various properties of the components of the ear cleaning solutions and drops.

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“…Most products contain one or more ingredients with antimicrobial activity and other components such as ceruminolytics, astringents, stabilisers and surfactants, which increase the solubility and activity of the antiseptic. A number of studies have reported antibacterial and antifungal activity of commercial ear cleaners or their components (Lloyd et al 1998, Cole et al 2003, Rème et al 2006, Swinney et al 2008, Guardabassi et al 2010, Mason et al 2013, Chan et al 2019, but most of these studies are in vitro while in vivo assays are few and far between.…”

Section: Introductionmentioning

confidence: 99%

Preliminary evaluation of two commercial ear solutions in the treatment of canine otitis externa

Fregeneda‐Grandes

Nicolás‐González

Rejas

et al. 2020

J of Small Animal Practice

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Objectives Preliminary evaluation of the efficacy of two commercial ear solutions composed of (1) chlorhexidine‐Tris‐ethylenediaminetetraacetic acid (EDTA) or (2) medical grade honey, for the treatment of otitis externa in dogs. Materials and Methods Dogs affected with otitis externa housed in an animal shelter were eligible for inclusion. Treatment was applied daily for 10 days and effect was measured by otitis clinical scores and microbiological counts. One of the treatments was applied to affected left ears, while the other was applied to affected right ears. Results A total of 24 ears from 13 dogs were included in the study. During the treatment period, with both treatments it was observed an improvement in clinical scores and a decrease in microbiological counts. At the end of the study 22 of 24 ears were deemed to have mild (4 ears), or no (18 ears) pain, with only two ears still showing pruritus. Clinical Significance The application of ear solutions composed of chlorhexidine‐Tris‐EDTA or medical grade honey, in the absence of antimicrobial treatment, might be effective for the control of clinical signs and microbial colonisation in dogs with otitis externa. Additional randomised studies on clinical patients are required to validate these findings.

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Study to assessin vitroantimicrobial activity of nine ear cleaners against 50Malassezia pachydermatisisolates

Abstract: Ear cleaners with activity against Malassezia may help to reduce the unnecessary use of antibiotic-containing polypharmaceutical ear medications. This study shows that the use of a large number of isolates may provide a more accurate account of the in vitro activity of a product.

Cited by 16 publications

References 33 publications

Biology, diagnosis and treatment ofMalasseziadermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

Biology, diagnosis and treatment ofMalasseziadermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

Topical ear treatment – options, indications and limitations of current therapy

Preliminary evaluation of two commercial ear solutions in the treatment of canine otitis externa

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