Study to explore the mechanism to form inclusion complexes of β-cyclodextrin with vitamin molecules

Saha, Subhadeep; Roy, Anshuman; Roy, Kanak; Roy, Mahendra Nath

doi:10.1038/srep35764

Cited by 172 publications

(127 citation statements)

References 61 publications

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“…It has been found that γ values, in both the cases, was increasing with increasing concentration of CDs and (Figure ), may be due to the insertion of the IL molecule inside the CD cavity from the bulk forming inclusion complexes. (Figure 8) . Also at a certain concentration of CD a sudden break point arrived and after that the curve becomes almost flattened (Figure ).…”

Section: Resultsmentioning

confidence: 85%

“…Study of UV‐Vis spectroscopy is a strong tool to calculate the association constant ( K a ) for the formation of ICs . In the host guest inclusion complexation when the ILs (act as chromophore) is encapsulated in the cavity of CD from the comparatively more polar bulk, there occurs a change of the molar extinction coefficient (Δϵ) of the IL .…”

Section: Resultsmentioning

confidence: 99%

“…Association constants ( K a c ) were also calculated for the inclusion complexation of IL and CD by means of conductivity study with the help of a nonlinear program ,. Basing upon the fact that the insertion of the IL inside the CD cavity change the conductivity of the solutions …”

Section: Resultsmentioning

confidence: 99%

“…The values of

Δ H^{0}

and

Δ S^{0}

obtained from both the procedures are expressed in Table 5. From the change of enthalpy and entropy values, the change in the Gibb's free energy was calculated at 298.15 K using the entropy and enthalpy values ,

true 2.303 prefixlog K_{f} = - \frac{Δ H^{0}}{R T} + \frac{Δ S^{0}}{R}

…”

Section: Resultsmentioning

confidence: 99%

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Sustenance of Inclusion Complexes of Ionic Liquid with Cyclic Oligosaccharide Molecules in Liquid and Solid Phases by Diverse Approaches

2018

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The water soluble inclusion complexes of pyridinium based hydrophobic ionic liquid (IL) were prepared and characterised successfully. The inclusion complexes of sparingly soluble IL prepared with α‐ and β‐cyclodextrin in the mixed solvent medium and in solid state were studied by different physicochemical methodologies. Comparison of the chemical shift of the pure CDs, guest and complexes formed in 1‐H NMR spectra, appearance of the cross peaks in 2D‐ROESY spectra and shift in the band positions in FT‐IR spectra confirmed the formation of inclusion complexes. Surface tension and conductance studies in the mixed solvent system indicated the 1:1 stoichiometric ratio of inclusion complex. Job's plot obtained from UV‐Vis study and the spectra obtained from mass spectrometric study supported the formation as well as the stoichiometry of inclusion complexes. The high binding constant values and calculated values of thermodynamic parameters such as Gibb's free energy, enthalpy and entropy supported the high stability and feasibility of formation of the inclusion complex.

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Section: Resultsmentioning

confidence: 85%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…The values of

Δ H^{0}

and

Δ S^{0}

true 2.303 prefixlog K_{f} = - \frac{Δ H^{0}}{R T} + \frac{Δ S^{0}}{R}

…”

Section: Resultsmentioning

confidence: 99%

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Sustenance of Inclusion Complexes of Ionic Liquid with Cyclic Oligosaccharide Molecules in Liquid and Solid Phases by Diverse Approaches

2018

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“…Corresponding to their molecular structure and shape, they acquire a unique ability of entrapping guest molecules in their internal cavity. As a result, a host‐guest complex is formed between cyclodextrins and guest molecules ,. Among the mentioned cyclodextrins, β‐CD is the most widely used as they are easily accessible due to its appropriate internal cavity diameter and high water‐solubility .…”

Section: Introductionmentioning

confidence: 99%

A Liquid‐Crystal‐Based System for Differentiating Structurally Related Analytes

Mishra

Singh

2018

ChemistrySelect

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We report a new approach for differentiating structurally related analytes using a liquid crystal (LC) based system. In this work we have combined two principles (analyte‐surfactant interactions and host‐guest inclusion) at LC/aqueous interface to differentiate structurally related analytes methyl red (MR) and methyl orange (MO). On introducing MR/MO in aqueous solution containing sodium dodecyl sulfate (SDS), the optical response of 4‐cyano‐4′‐pentylbiphenyl (5CB) changes from dark to bright in presence of MR but remains same in the presence of MO. This observation implies interaction of analyte (MR) and surfactant (SDS), thus effectively displacing SDS adsorbed at the 5CB/aqueous interface. Further, competitive inclusion complex formation of β‐cyclodextrin (β‐CD) with SDS or with analyte (dye, MR/MO) was visualized through changes in the optical response of 5CB at SDS‐laden 5CB/aqueous interface. On addition of MR/MO to the SDS‐β‐CD complex solution the optical response of 5CB changes from bright to dark in presence of MO but remains same in the presence of MR. This implicates that homeotropic orientation of 5CB resulted due to the reorganization of displaced SDS molecules from β‐CD cavity at the 5CB/aqueous interface. Overall, this LC based system demonstrates differentiation of structurally related analytes in the absence and presence of β‐CD.

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