Studying antibiotic persistence in vivo using the model organism Salmonella Typhimurium

Newson, Joshua PM; Gaissmaier, Marla Sofie; McHugh, Sarah C; Hardt, Wolf‐Dietrich

doi:10.1016/j.mib.2022.102224

Cited by 6 publications

(2 citation statements)

References 83 publications

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“…However, in vitro studies are not always suitable to reflect in vivo situations and animal studies would dramatically improve the physiological relevance of the results. [178][179][180] In an intriguing approach, Waldor et al have analysed microbe-host interactions at the bacterial envelope by biotinylation of proteins associated with the surface of V. cholerae isolated from an infant rabbit model. 181 This approach revealed that numerous host proteins associate with V. cholerae and that their abundance on the pathogen surface is driven by the presence of cholera toxin.…”

Section: Discussionmentioning

confidence: 99%

Monitoring host–pathogen interactions using chemical proteomics

Weigert Muñoz,

Zhao,

Sieber

2024

RSC Chem. Biol.

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Section: Discussionmentioning

confidence: 99%

Monitoring host–pathogen interactions using chemical proteomics

Weigert Muñoz,

Zhao,

Sieber

2024

RSC Chem. Biol.

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“…Therefore, it is critical to contextualize basic research findings in in vivo mammalian models or clinical settings (Box 1). Recent research conducted with murine models appears to hold great potential for translating in vitro findings (Newson et al , 2022; preprint: Verstraete et al , 2022a). Additionally, several promising strategies have been proposed to combat antibiotic persistence, but their efficacy is yet to be validated.…”

Section: Introductionmentioning

confidence: 99%

Environmental, mechanistic and evolutionary landscape of antibiotic persistence

et al. 2023

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Recalcitrant infections pose a serious challenge by prolonging antibiotic therapies and contributing to the spread of antibiotic resistance, thereby threatening the successful treatment of bacterial infections. One potential contributing factor in persistent infections is antibiotic persistence, which involves the survival of transiently tolerant subpopulations of bacteria. This review summarizes the current understanding of antibiotic persistence, including its clinical significance and the environmental and evolutionary factors at play. Additionally, we discuss the emerging concept of persister regrowth and potential strategies to combat persister cells. Recent advances highlight the multifaceted nature of persistence, which is controlled by deterministic and stochastic elements and shaped by genetic and environmental factors. To translate in vitro findings to in vivo settings, it is crucial to include the heterogeneity and complexity of bacterial populations in natural environments. As researchers continue to gain a more holistic understanding of this phenomenon and develop effective treatments for persistent bacterial infections, the study of antibiotic persistence is likely to become increasingly complex.

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Biological Insights from RNA–RNA Interactomes in Bacteria, as Revealed by RIL-seq

Silverman,

Melamed

2024

Methods in Molecular Biology

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Studying antibiotic persistence in vivo using the model organism Salmonella Typhimurium

Cited by 6 publications

References 83 publications

Monitoring host–pathogen interactions using chemical proteomics

Monitoring host–pathogen interactions using chemical proteomics

Environmental, mechanistic and evolutionary landscape of antibiotic persistence

Biological Insights from RNA–RNA Interactomes in Bacteria, as Revealed by RIL-seq

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