Studying cognitive function in patients with a long-standing diagnosis of SWEDD

Jesuthasan, Aaron; Garcia, Lucas Rogerio; Pavese, Nicola

doi:10.1016/j.jns.2022.120353

Cited by 1 publication

(2 citation statements)

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“…In connection with cognitive function, SWEDD subgroups have been shown to possess similar cognitive symptoms irrespective of their final clinical diagnosis 38. Moreover, some patients with idiopathic PD with SWEDD demonstrated early cognitive decline, suggesting that patients with SWEDD may be at even greater risk for cognitive decline than patients with DaTSCAN-positive early-stage PD 39.…”

Section: Discussionmentioning

confidence: 99%

“…In connection with cognitive function, SWEDD subgroups have been shown to possess similar cognitive symptoms irrespective of their final clinical diagnosis. 38 Moreover, some patients with idiopathic PD with SWEDD demonstrated early cognitive decline, suggesting that patients with SWEDD may be at even greater risk for cognitive decline than patients with DaTSCAN-positive early-stage PD. 39 In this study, MMSE scores both at baseline and follow-up in SWEDD patients showed no significant difference compared with those in age-matched controls, and moreover, no significant difference was observed between SWEDD patients at baseline and follow-up, probably because of the early stages of the disease or the short period of follow-up.…”

Section: Discussionmentioning

confidence: 99%

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Long-term follow-up study of SWEDD patients with mild parkinsonian signs

Sasaki

2024

BMJ Neurol Open

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BackgroundWhether scan without evidence of dopaminergic deficit (SWEDD) can be a reliable indication of a clinical entity of Parkinson’s disease (PD) is controversial.ObjectiveTo evaluate the proportion of SWEDD patients with mild parkinsonian signs who are classifiable as idiopathic PD.Methods32 SWEDD patients with unilateral or asymmetric finger tremor with a rest component and unilateral rigidity (Unified Parkinson’s Disease Rating Scale (UPDRS)-III scores of 3-5) were enrolled. They underwent longitudinal examination by UPDRS-III, Mini–Mental State Examination (MMSE), smell test and123I-FP-CIT SPECT (DaTSCAN) at baseline (first DaTSCAN) and at follow-up (second DaTSCAN) after 27–83 months. Age-matched controls (n=112) also underwent MMSE and smell test.ResultsAt follow-up, 21 of 32 SWEDD patients (65.6%) showed significantly reduced specific binding ratios below the normal range, that is, positive DaTSCAN, sometimes with increased asymmetry index (n=11). Among these 21 patients, the mean (SD) UPDRS-III score at follow-up was significantly higher than that at baseline (5.5 (2.2) vs 4.0 (0.5)) (p=0.003). The mean (SD) MMSE scores in SWEDD patients (n=32) at baseline and follow-up were not significantly different compared with those in controls. Olfactory function both in SWEDD patients with positive and negative DaTSCAN was significantly impaired versus controls (p<0.001), although no significant difference was recognised between patients with positive (n=21) and negative (n=11) second DaTSCAN.ConclusionThe majority of SWEDD patients with mild rest tremor and rigidity could be classified as having idiopathic PD in this longitudinal and long-term follow-up study.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%