2023
DOI: 10.3390/jof9020174
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Studying Fungal-Bacterial Relationships in the Human Gut Using an In Vitro Model (TIM-2)

Abstract: The complex microbial community found in the human gut consist of members of multiple kingdoms, among which are bacteria and fungi. Microbiome research mainly focuses on the bacterial part of the microbiota, thereby neglecting interactions that can take place between bacteria and fungi. With the rise of sequencing techniques, the possibilities to study cross-kingdom relationships has expanded. In this study, fungal-bacterial relationships were investigated using the complex, dynamic computer-controlled in vitr… Show more

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Cited by 2 publications
(1 citation statement)
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“…Intriguingly, both studies evidenced that tetracycline treatment correlated with escalated fungal concentrations, thus corroborating findings from our own study. More recently, Maas and colleagues also engaged in investigating the interplay between bacteria and fungi using the TIM-2 fermentation model [ 79 , 80 ]. Their focus encompassed diet modulation as well as the application of antifungal and antibacterial treatments.…”
Section: Discussionmentioning
confidence: 99%
“…Intriguingly, both studies evidenced that tetracycline treatment correlated with escalated fungal concentrations, thus corroborating findings from our own study. More recently, Maas and colleagues also engaged in investigating the interplay between bacteria and fungi using the TIM-2 fermentation model [ 79 , 80 ]. Their focus encompassed diet modulation as well as the application of antifungal and antibacterial treatments.…”
Section: Discussionmentioning
confidence: 99%