Studying host-microbiota mutualism in Drosophila: Harnessing the power of gnotobiotic flies

Ma, Dandan; Storelli, Gilles; Mitchell, Mélanie; Leulier, François

doi:10.4103/2319-4170.158620

Cited by 58 publications

(49 citation statements)

References 50 publications

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“…The fl y gut is known to harbor commensal bacteria that regulate nutritional status and might help to provide pantothenate, as has been demonstrated in mammals (34)(35)(36). We observed measurable quantities of this nutrient in isolated guts, although no change in pantetheine or pantothenate levels was observed upon HS feeding (data not shown).…”

Section: Discussionmentioning

confidence: 58%

CoA protects against the deleterious effects of caloric overload in Drosophila

Musselman¹,

Fink

Baranski

2016

Journal of Lipid Research

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Section: Discussionmentioning

confidence: 58%

CoA protects against the deleterious effects of caloric overload in Drosophila

Musselman¹,

Fink

Baranski

2016

Journal of Lipid Research

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“…In this fast expanding research field, Drosophila has been a fruitful model. Thanks to its ease of manipulation and genetic tractability, as well as the low complexity of its microbiota, the fruit fly represents a powerful tool to delve into the mechanistic underpinnings of host–microbiota interactions (Lee and Brey, 2012; Ma et al, 2015). Studies have revealed that the presence and composition of microbiota impact various traits throughout the Drosophila life cycle such as larval growth, developmental timing, stress resistance, immune response, metabolism, lifespan and behavior (Brummel et al, 2004; Ryu et al, 2008; Sharon et al, 2010; Shin et al, 2011; Guo et al, 2014; Petkau et al, 2014; Venu et al, 2014; Wong et al, 2014; Clark et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus plantarum favors the early emergence of fit and fertile adult Drosophila upon chronic undernutrition

Téfit

Leulier

2017

Journal of Experimental Biology

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Animals are naturally surrounded by a variety of microorganisms with which they constantly interact. Among these microbes, some live in close association with a host and form its microbiota. These communities are being extensively studied, owing to their contributions to shaping various aspects of animal physiology. One of these commensal species, Lactobacillus plantarum, and in particular the L.p.WJL strain, has been shown to promote the growth of Drosophila larvae upon nutrient scarcity, allowing earlier metamorphosis and adult emergence compared with axenic individuals. As for many insects, conditions surrounding the post-embryonic development dictate key adult life history traits in Drosophila, and adjusting developmental timing according to the environment is essential for adult fitness. Thus, we wondered whether the growth acceleration induced by L.p.WJL in a context of poor nutrition could adversely impact the fitness of Drosophila adults. Here, we show that the L.p.WJL-mediated acceleration of growth is not deleterious; adults emerging after an accelerated development are as fit as their axenic siblings. Additionally, the presence of L.p.WJL even leads to a lifespan extension in nutritionally challenged males. These results demonstrate that L.p.WJL is a beneficial partner for Drosophila melanogaster through its entire life cycle. Thus, commensal bacteria allow the earlier emergence and longer survival of fit and fertile individuals and might represent one of the factors contributing to the ecological success of Drosophila.

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“…In the second review, Ma et al [8] discuss the value of gnotobiotic flies as an experimental system. One drawback of the fly microbiota is that it is transient and constantly replenished, such that the microbial community changes drastically with age.…”

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confidence: 99%

Lessons from theDrosophila microbiota

Walton¹

2015

Biomed J

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This issue of the Biomedical Journal includes two reviews discussing how studying the gut of the humble fruit fly can reveal important insight about our own microbial communities. In addition, we focus on work showing that acupuncture may not be the best treatment for idiopathic chronic pelvic pain. Finally, we report on several studies that will hopefully help to optimize surgical techniques, from laser treatment for birthmarks to the design of prostheses for radial head fractures. (Biomed J 2015;38:271-274)

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Studying host-microbiota mutualism in Drosophila: Harnessing the power of gnotobiotic flies

Cited by 58 publications

References 50 publications

CoA protects against the deleterious effects of caloric overload in Drosophila

CoA protects against the deleterious effects of caloric overload in Drosophila

Lactobacillus plantarum favors the early emergence of fit and fertile adult Drosophila upon chronic undernutrition

Lessons from theDrosophila microbiota

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