Studying levels of homocysteine in diagnosed cases of polycystic ovary syndrome

Suleiman, Rojeen Rasheed; Sulaiman, Dhia Mustafa

doi:10.4103/mjbl.mjbl_94_18

Cited by 4 publications

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“…Suleiman RR, et al found significant high homocysteine level in PCOS patients compared to control. They also showed there was no significant difference in homocysteine levels between the BMI categories and marital status in PCOS cases and controls 3 . Our study coincides with study done by Priyanka Maleedhu et al which showed the increase in homocysteine was associated with increase in BMI and waist circumference in PCOS cases.…”

Section: Discussionmentioning

confidence: 95%

“…Clinical features seen in PCOS are menstrual irregularities, hirsutism, obesity, infertility, anovulation, and acne. PCOS is also linked with obesity, insulin resistance, and metabolic syndrome leading to complications like cardiovascular diseases and diabetes mellitus 3 . Homocysteine (hcy), an amino acid, is an intermediary product of methionine metabolism.…”

Section: Introductionmentioning

confidence: 99%

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Association of BMI with Serum Homocysteine in Polycystic Ovarian Syndrome Women

Roshni G. Sadaria,

Smita N. Vasava

2021

Indian Journal of Forensic Medicine & Toxicology

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Background: Women of reproductive age group are prone for Polycystic ovarian syndrome (PCOS). Recent studies have shown that hyperhomocysteinemia is a risk factor for cardiovascular diseases. Prevalence of cardiovascular disease and cardiovascular morbidities in women with PCOS are increased nowadays. The purpose of the study is to assess correlation of BMI with serum homocysteine in PCOS females. Materials and Methods:This is done on 50 PCOS patients and 50 voluntary age matched healthy women with no menstrual abnormalities as controls. The age group for the cases and controls is 18-35 years. The study was conducted at

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Association of BMI with Serum Homocysteine in Polycystic Ovarian Syndrome Women

Roshni G. Sadaria,

Smita N. Vasava

2021

Indian Journal of Forensic Medicine & Toxicology

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“…Altered sex steroid production, metabolic dysfunction, and obesity may all contribute to the changes in LH secretion pattern (13), Insulin resistance/hyperinsulinemia may directly or indirectly contribute to the abnormal gonadotropin secretion (14). It was found that PCOS women had infertility rate 66% in the study ( 15) and 68% in ( 16).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of some hematological and biochemical parameters for women with polycystic ovary syndrome in Wasit Governorate

Khudhair

2023

wjps

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The aim of the study; the Study of physiological causes and risk factors of ovarian cysts in women and Analyzing the results statistically to determine the extent of the relationship between the physiological and biochemical causes of the occurrence of polycysticovaries. Polycystic ovary syndrome (PCOS) is one of the commonest endocrine disorders affecting many females in reproductive period which start from menarche till the menopause and commonly caused infertility around the world, and is characterized by irregular menstrual cycle, Hyperandrogensim and polycystic ovary; it can be considered a conditions involving reproductive, metabolic and cardiovascular components leading to lifelong health implication. Its prevalence among infertile women is between (15% to 20%). There is evidence that PCOS is a pro inflammatory disorder, characterized by the presence of low grade chronic inflammation that correlated with obesity or insulin resistance (IR). The purpose of this study is to investigate the role of study included 100 females diagnosed with PCOS, there were recruited from Al-kut hospital in Wasit during November 2022 until January 2023 , the diagnosis of polycystic ovary syndrome was based on the Rotterdam 2003 criteria. The control group consists of 50 fertile women who have regular menstrual cycle with no sign of hyperandrogenism and subjected to ultrasound examination and have normal hormonal levels. The age was identical in both groups and it was between (20-40) years. . Body mass index (BMI) for both patients and control group was calculated. The questionnaire form has been filled for each patient and control. Hormones levels luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) were estimated. The present study was carried out in two parts: immunological and physiological study. ELISA technique has been used to determine the serum level of High –sensitivity C-reactive protin(Hscrp) . The results of Hscrp serum level was significantly increased (p<0.oo5) in pcos patient(17.38+1.36) The results for physiological study demonstrated that insulin serum level recorded a highly significant difference (p <0.05) in PCOS patients compared to control group, the mean level of this hormone for PCOS patients and control were (17.18±2.84) μIU/mL, (8.68±1.97) μIU/mL respective. While this study showed there were no significant differences in serum levels of T.protin, and TSH between PCOS patients (8.08± 1,28). ng/mL(, 0.79±0.17)μg/dL, and control group (7.09±0.51) ng/mL,( 1.20±0.09) μg/dL. This study illustrate that the serum levels of Hscrp and insulin were elevated in PCOS comparing to healthy women and this high levels related to PCOS independent on the presence of obesity or IR., and there was a positive correlation between the insulin hormone with the parameters Hscrp and this may be due to the background of PCOS which considered as inflammatory disease The reslts showed that ,Creatin ,cholesterol,GPT, and LDL ,Lympho ,TG were significantly increased in pcos patients than control group

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Homocysteine, vitamin B12, and folate circulating levels in women with and without polycystic ovary syndrome: A systematic review and meta-analysis

Ulloque-Badaracco,

Al-kassab-Córdova,

Hernández-Bustamante

et al. 2024

Womens Health (Lond Engl)

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Background: Some studies have reported that homocysteine, vitamin B12, and folic acid levels are associated with polycystic ovary syndrome (PCOS), whereas other studies yielded controversial results. Objectives: This study aimed to systematize the available evidence of homocysteine, vitamin B12, and folate levels in women with and without PCOS. Design: Systematic review and meta-analysis Data Sources and Methods: A systematic search without language restrictions was performed on PubMed, Ovid/Medline, Scopus, Embase, and Web of Science. In addition, the reference lists of the selected studies were reviewed. The Newcastle–Ottawa Scale was employed to evaluate the quality of studies. The means and standard deviations of the outcomes were pooled as standardized mean differences (SMDs) with 95% confidence intervals (CI). Furthermore, the DerSimonian and Laird method was employed for the quantitative synthesis. Results: A total of 75 studies met the eligibility criteria for at least one outcome. Patients with PCOS had higher circulating homocysteine levels than those without (SMD: 0.82; 95% CI: 0.62–1.02, n = 70 studies, p < 0.001). This trend remained in the sensitivity and subgroup analyses by world regions of studies, assay methods, and insulin resistance. No significant differences were observed in circulating vitamin B12 (SMD: −0.11; 95% CI: −0.25 to 0.03; n = 17 studies, p = 0.13) and folate levels (SMD: −0.2; 95% CI: −0.68 to 0.27; n = 17 studies, p = 0.41) between patients with and without PCOS. Conclusions: (i) Patients with PCOS exhibited significantly higher homocysteine levels than those without, and (ii) no significant differences were observed in both vitamin B12 and folate levels in women with and without PCOS. Registration: PROSPERO ID (CRD42023432883)

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Studying levels of homocysteine in diagnosed cases of polycystic ovary syndrome

Cited by 4 publications

References 0 publications

Association of BMI with Serum Homocysteine in Polycystic Ovarian Syndrome Women

Association of BMI with Serum Homocysteine in Polycystic Ovarian Syndrome Women

Evaluation of some hematological and biochemical parameters for women with polycystic ovary syndrome in Wasit Governorate

Homocysteine, vitamin B12, and folate circulating levels in women with and without polycystic ovary syndrome: A systematic review and meta-analysis

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