Studying Neudesin marker in Iraqi Thyroid Dysfunction Patients

Abstract

Thyroid dysfunctions (TDs) are the most common endocrine diseases, especially in women. Phrase "thyroid dysfunction" refers to a variety of diseases affecting the thyroid gland and its hormones. This study aims to compare serum neudesin levels and lipid profiles between people with and without thyroid dysfunction. Study involved 56 TDs patients from a medical laboratory and 28 healthy controls (HCs). Neudesin concentration in serum was assessed using an enzyme-linked immunosorbent test (ELISA), whilst triglycerides (TGs), total cholesterol (T. Cho), High-density lipoprotein cholesterol (HDL-C) and total cholesterol levels were measured using enzyme colorimetry. Serum level of neudesin was lower in thyroid dysfunction patients than in HCs (P< 0.000l), neudesin has an important negative correlation with TGs, HDL, and very low-density lipoprotein (VLDL) (mg/dL) (P< 0.000l), while it showed a positive correlation with low-density lipoprotein (LDL) (mg/dL) (P < 0.000l). Studied parameters showed of the areas under the receiver operating characteristic (AUROC) curve hypothyroidism and hyperthyroidism, respectively: Neudesin (0.8017 and 0.9043 ng/mL), HDL (0.677 and 0.5708 mg/dL), triiodothyronine (T3) (0.8578 and 1 nmol/L), thyroxine (T4) (0.9872 and 1 nmol/L), thyroid-stimulating hormone (TSH) (0.9847 and 0.757 mIU/mL), T. Cho. (0.909 and 0.6645 mg/dL), TGs (0.944 and 0.669 mg/dL), VLDL (0.942 and 0.669 mg/dL), and LDL (0.872 and 0.7526 mg/dL). Present study found serum levels of neudesin showed a negative correlation with T.Cho, and LDL in hyperthyroidism patients while showing a negative correlation with triglycerides and VLDL in hypothyroidism patients. .