Studying the Age of Onset and Detection of Chronic Myeloid Leukemia Using a Three-Stage Stochastic Model
SURYADEEPTO NAG,
ANANDA SHIKHARA BHAT,
SIDDHARTHA P. CHAKRABARTY
Abstract:Chronic Myeloid Leukemia (CML) is a biphasic malignant clonal disorder that progresses, first with a chronic phase, where the cells have enhanced proliferation only, and then to a blast phase, where the cells have the ability of self-renewal. It is well recognized that the Philadelphia chromosome (which contains the BCR-ABL fusion gene) is the “hallmark of CML”. However, empirical studies have shown that the mere presence of BCR-ABL may not be a sufficient condition for the development of CML, and further modi… Show more
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