Studying the Association between Sudden Hearing Loss and DNA N-Methyltransferase 1 (DNMT1) Genetic Polymorphism

Abstract

This study's results showed that the AA genotype in rs2228611 polymorphism was a risk factor in ISSHL patients and the GG genotype could be a protective factor in rs2228612 polymorphism.

The Inheritance of Hearing Loss and Deafness: A Historical Perspective

“…Metal overload and epigenetic changes may also affect the cochlea or the sensorial epithelium, playing a role in various forms of sensorineural hearing loss. [77,78]. These facts were observed by the same group, describing how iron homeostasis genes predispose to one of the most difficult and complex forms of hearing loss, i.e., idiopathic sudden sensorineural hearing loss [79].…”

Utilizing Single Cell RNA-Sequencing to Implicate Cell Types and Therapeutic Targets for SSNHL in the Adult Cochlea

“…Increased risk was determined by a significantly higher SNP frequency observed in affected SSNHL subjects compared to controls. In contrast, the following seven genes had at least one SNP correlated with a decreased risk: APOE , DNMT1 , FCRL3 , GRHL2 , GPX3, HSPA1A , SERPINE1 (23–29) (Supplemental Digital Content, Table 1, http://links.lww.com/MAO/B337). Decreased risk was inferred by the observation of a significantly lower SNP frequency in SSNHL subjects compared to controls, or by a significantly higher SNP frequency in controls compared to SSNHL subjects.…”

“…Decreased risk was inferred by the observation of a significantly lower SNP frequency in SSNHL subjects compared to controls, or by a significantly higher SNP frequency in controls compared to SSNHL subjects. Interestingly, there were two genes, DNMT1 and FCRL3, for which specific genotypes in different SNPs of each gene were found to have opposite associations with SSNHL risk (23,25).…”

A Systematic Review on Heritability of Sudden Sensorineural Hearing Loss

“…Twenty-two genetic studies were included. 5,7,[26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] These genetic studies sought to find genetic variants associated with the development of SSNHL and their results are summarized in Table IV.…”

“…6 Only 10%-15% of cases have known causes, and the rest are considered idiopathic. 1,7 The heritability of SSNHL is largely unknown, and few studies have compared SSNHL prevalence among populations with different ethnic backgrounds or explored familial aggregation. Some genetic studies have identified allelic variants potentially linked to an increased risk of SSNHL, particularly in prothrombotic factors.…”