We have extended through β 23 the high-temperature expansion of the second field derivative of the susceptibility for Ising models of general spin, with nearest-neighbor interactions, on the simple cubic and the body-centered cubic lattices. Moreover the expansions for the nearest-neighbor correlation function, the susceptibility and the second correlation moment have been extended up to β 25 . Taking advantage of these new data, we can improve the accuracy of direct estimates of critical exponents and of hyper-universal combinations of critical amplitudes such as the renormalized fourpoint coupling gr or the quantity usually denoted by R + ξ . In particular, we obtain γ = 1.2371(1), ν = 0.6299(2), γ4 = 4.3647(20), gr = 1.404(3) and R + ξ = 0.2668(5). We have used a variety of series extrapolation procedures and, in some of the analyses, we have assumed that the leading correctionto-scaling exponent θ is universal and roughly known. We have also verified, to high precision, the validity of the hyperscaling relation and of the universality property both with regard to the lattice structure and to the value of the spin.