Studying the effects of profenofos, an endocrine disruptor, on organogenesis of zebrafish

Sultana, Zakia; Khan, Mst Mansura; Mostakim, Golam Mohammod; Moniruzzaman,; Rahman, Khalilur; Shahjahan, Md; Islam, Mohammad Nazrul

doi:10.1007/s11356-020-11944-0

Cited by 12 publications

(1 citation statement)

References 35 publications

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“…It is extremely hazardous to crustaceans (Blue crab, Callinectes sapidus, has an LC 50 value of 33.0 µg/L), zooplankton (Immature scud, Gammarus pseudolimnaeus, has a 96 h LC 50 value of 1.30 µg/L), Bluegill (300 µg/L), Crucian carp (90.0 µg/L), and Rainbow trout (80.0 µg/L) (Tomlin 1994). 62.4 µg/L was a 96 h LC 50 value for common carp (Ismail et al 2009), and 0.057 mg/L was LC 50 for zebrafish (Sultana et al 2021). However, studies on PROmediated toxicities in grass carp are still scanty.…”

Section: Introductionmentioning

confidence: 99%

Toxicity bioassay and sub-lethal effects of profenofos-based insecticide on behavior, biochemical, hematological, and histopathological responses in Grass carp (Ctenopharyngodon idella)

et al. 2023

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Profenofos (organophosphate) is among the major toxicant polluting freshwater bodies, exerting a significant effect on fish health. The LC50 value of Profenofos (PRO) was resolved in Grass carp (Ctenopharyngodon idella) with average body weight (55.82 ± 5.42 g) and determined the 96 h LC50 value as 7.2 µg/L for the assay. Twenty-one-day exposures to 1.8 µg/ L and 3.6 µg/ L doses were conducted to evaluate the sub-lethal effects, and various toxicological endpoints were assessed on the 1st, 7th, 15th and 21st days of exposure. Acute toxic stress was observed with fish displaying behavioral toxicity. The most hematological change was extreme microcytic hypochromic anemia. Leucocyte count increased in experimented fish. Moderate neutrophilia, monocytosis and lymphocytosis were observed. Serum total protein, albumin, and globulin concentrations were significantly diminished. Overall, increments over control were recognized in serum urea, creatinine and acid phosphatase. However, serum glucose, total lipid, cholesterol, serum ALT and AST activity showed a significant decrease in fish exposed to both concentrations of PRO. Serum IgM concentrations insignificantly changed in treated fish except for on the 21st day of exposure to 3.6 µg/ L of PRO, while serum lysozyme significantly decreased. Furthermore, total protein, lipid and glycogen concentrations in muscles and the liver exhibited a decreasing trend at all concentrations. Moreover, histopathological alterations in the liver, kidney, and muscles occurred exclusively after treatment. From the obtained results, it is assumed that profenofos induced general toxic impacts under field conditions and might disturb ecologically relevant processes.

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Section: Introductionmentioning

confidence: 99%

Toxicity bioassay and sub-lethal effects of profenofos-based insecticide on behavior, biochemical, hematological, and histopathological responses in Grass carp (Ctenopharyngodon idella)

et al. 2023

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Sensitivity Variations in Developmental Toxicity of Imidacloprid to Zebrafish Embryos at Different Neurodevelopmental Stages

Xu,

Xie,

et al. 2024

Enviro Toxic and Chemistry

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Neonicotinoids are ubiquitous in global surface waters and pose a significant risk to aquatic organisms. However, information is lacking on the variations in sensitivity of organisms at different developmental stages to the neurotoxic neonicotinoids. We established a spectrum of toxicity to zebrafish embryos at four neurodevelopmental stages (1, 3, 6, and 8 h post fertilization [hpf]) and dechorionated embryos at 6 hpf based on external and internal exposure to imidacloprid as a representative neonicotinoid. Embryos at the gastrula stage (6 and 8 hpf) were more sensitive to imidacloprid than embryos at earlier developmental stages. Dechorionated embryos were more sensitive to imidacloprid than embryos with a chorion, suggesting that the chorion offers protection against pollutants. Nine sublethal effects were induced by imidacloprid exposure, among which uninflated swim bladder (USB) was the most sensitive. Water depth and air availability in the exposure chambers were critical factors influencing the occurrence of USB in zebrafish larvae. Internal residues of metabolites accounted for <10% of imidacloprid, indicating that imidacloprid was metabolized in a limited fashion in the embryos. In addition, acute toxicity of the main metabolite 5‐hydroxy‐imidacloprid was significantly lower than that of imidacloprid, indicating that the observed toxicity in embryos exposed to imidacloprid was mainly induced by the parent compound. Our research offers a fresh perspective on choosing the initial exposure time in zebrafish embryo toxicity tests, particularly for neurotoxicants. Environ Toxicol Chem 2024;43:2398–2408. © 2024 SETAC

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Effects of profenofos on the growth, reproduction, behavior, and gene transcription of Daphnia magna

Jin

et al. 2023

Environ Sci Pollut Res

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Studying the effects of profenofos, an endocrine disruptor, on organogenesis of zebrafish

Cited by 12 publications

References 35 publications

Toxicity bioassay and sub-lethal effects of profenofos-based insecticide on behavior, biochemical, hematological, and histopathological responses in Grass carp (Ctenopharyngodon idella)

Toxicity bioassay and sub-lethal effects of profenofos-based insecticide on behavior, biochemical, hematological, and histopathological responses in Grass carp (Ctenopharyngodon idella)

Sensitivity Variations in Developmental Toxicity of Imidacloprid to Zebrafish Embryos at Different Neurodevelopmental Stages

Effects of profenofos on the growth, reproduction, behavior, and gene transcription of Daphnia magna

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