Studying the Osmotic Activity of a Polycomponent Reparative Gel

Abstract

Abstract. Hydrogel-based wound dressings are currently in demand due to their positive effect on reparative processes. The range of such is quite diverse and is represented by gelling agents of both synthetic and natural origin. The latter are most often biopolymers, among which collagen deserves special attention. The most important properties of collagen are its biocompatibility, low level of immunogenicity, ability to biodegrade, which leads to the formation of degradation products that stimulate cell proliferation and the biosynthesis of native collagen. Collagen has optimal physical characteristics, which is important for ensuring the structural and mechanical properties of the compositions. In addition, collagen has been successfully used as a carrier for other pharmacologically active substances. In this regard, the expediency of developing a multicomponent gel with a predictable reparative effect based on collagen and a thick extract of maize columns with stigmas was shown. This medicinal plant raw material has anti-inflammatory, antioxidant, immunotropic effects, which suggests its positive effect on tissue healing processes. One of the important properties of the reparative gel is its osmotic activity, which determines the ability to absorb exudate and cleanse the surface of the wound from purulent secretions, reduce tissue hyperthermia and inflammatory edema. The purpose of this study is to study the osmotic activity of a multicomponent gel of reparative action based on collagen and a thick extract of maize columns with stigmas. The object of the study was experimental samples of a polycomponent gel. Osmotic activity was studied by the method of equilibrium dialysis according to Kruvchinsky. For the purpose of a comparative assessment of the osmotic activity of a multicomponent gel, a control study was carried out in parallel under the same conditions for a 0.9% sodium chloride solution. The results obtained demonstrated the presence of hyperosmolar characteristics in the experimental samples of the polycomponent gel during the first four hours of dialysis, which allows us to predict its positive effect on the processes of cleansing damaged tissues from pathological secretions and their effective repair.