Studying the pharmacogenomic effect of cranberry extract on reducing body weight using collaborative cross mice

Amer-Sarsour, Fatima; Saleh, Rawan Abu; Ofek, Itzhak; Iraqi, Fuad A.

doi:10.1039/d0fo02865g

Cited by 3 publications

(4 citation statements)

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“…In the current study, we have demonstrated variations in the effect of NDM on reducing FBG, which is also explained by variations in host genetic background. These results also agree with our recent results showing the effect of NDM on reducing body weight, which is again explained by host genetic background 29 …”

Section: Discussionsupporting

confidence: 93%

“…[20][21][22][23][24][25][26][27][28] Recently, we have shown that the host genetics background shapes the pharmacogenetics effect of NDM on reducing body weight using the CC mouse population. 29 Here, we present results…”

Section: Introductionmentioning

confidence: 71%

“…Recently, we have shown that the host genetics background shapes the pharmacogenetics effect of NDM on reducing body weight using the CC mouse population 29 . Here, we present results showing that the NDM effect in lowering fasting blood glucose (FBG) levels in CC mice is significantly dependent on the genetic background of the mice (pharmacogenetics), the sex of the mice (pharmacosex) and diet (pharmacodiet).…”

Section: Introductionmentioning

confidence: 81%

“…These results also agree with our recent results showing the effect of NDM on reducing body weight, which is again explained by host genetic background. 29 A drawback of the present study is the issue of and mode of administration of the NDM. The dose of NDM (50 mg/kg mouse body weight) employed in the present study is ¼ of that employed in previous studies.…”

Section: Malesmentioning

confidence: 90%

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Lowering fasting blood glucose with non‐dialyzable material of cranberry extract is dependent on host genetic background, sex and diet

Amer-Sarsour

Tarabeih

Ofek

et al. 2022

Anim Models and Exp Med

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Background: Type 2 diabetes (T2D) is a polygenic metabolic disease, characterized by high fasting blood glucose (FBG). The ability of cranberry (CRN) fruit to regulate glycemia in T2D patients is well known. Here, a cohort of 13 lines of the genetically diverse Collaborative Cross (CC) mouse model was assessed for the effect of non-dialyzable material (NDM) of cranberry extract in lowering fasting blood glucose.Methods: Eight-week-old mice were maintained on either a standard chow diet (control group) or a high-fat diet (HFD) for 12 weeks, followed by injections of intraperitoneal (IP) NDM (50 mg/kg) per mouse, three times a week for the next 6 weeks.Absolute FBG (mg/dl) was measured bi-weekly and percentage changes in FBG (%FBG) between weeks 0 and 12 were calculated.Results: Statistical analysis showed a significant decrease in FBG between weeks 0 and 12 in male and female mice maintained on CHD. However, a non-significant increase in FBG values was observed in male and female mice maintained on HFD during the same period. Following administration of NDM during the following 6 weeks, the results show a variation in significant levels of FBG lowering between lines, male and female mice and under the different diets. Conclusion:The results suggest that the efficacy of NDM treatment in lowering FGB depends on host genetic background (pharmacogenetics), sex of the mouse (pharmacosex), and diet (pharmacodiet). All these results support the need for follow-up research to better understand and implement a personalized medicine approach/utilization of NDM for reducing FBG. K E Y W O R D Schow diet (CHD), collaborative cross (CC) mouse model, fasting blood glucose (FBG), high-fat diet (HFD), non-dialyzable material (NDM) of cranberry extract, type 2 diabetes (T2D)

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Section: Discussionsupporting

confidence: 93%