Studying the role of estrogen receptor alpha in the developmental toxicity of diethylstilbestrol using alternative testing strategies

Abstract

Table of Contents Chapter 1 General Introduction Chapter 2 Estrogen receptor alpha (ERα)-mediated coregulator binding and gene expression discriminates the toxic ERα agonist diethylstilbestrol (DES) from the endogenous ERα agonist 17β-estradiol (E2) Chapter 3 The in vivo developmental toxicity of diethylstilbestrol (DES) in rat evaluated by an alternative testing strategy Chapter 4 Assessment of the in vitro developmental toxicity of diethylstilbestrol and estradiol in the zebrafish embryotoxicity test Chapter 5 Physiologically based kinetic modelling-facilitated comparison of internal female dose levels of diethylstilbestrol and 17βestradiol, to study a potential role of kinetics in the differences in their developmental toxicity Chapter 6 General Discussion