Studying the Synergistic Effect of both Propolis Extract and Green Apple Peel Extract with Fluconazole against Candida albicans

Abstract

Candida albicans were isolated from 36 isolates of the mouth people aged (2.5-63) years. A crude sample of bees propolis was collected from several apiaries in Mosul city and green apples were collected from the markets, evaluating antifungal of fluconazole, methanol extract of propolis (MPE) and methanol extract of green apples peels (MEGAP) were different concentration (125,250,375,500,750,1000,1500)ug/ml, each one alone and as combination of (fluconazole 50%+ MPE 50%) and of (fluconazole 50%+ MEGAP50%). Each one alone, the fluconazole only had inhibitory effect against C.albicans. As combination, the synergistic effect was observed of both combination (fluconazole 50% + EMP 50%) and (fluconazole 50%+MEGAP 50%) against C.albicans. In comparing between two combination observed that it was outdoing in a synergistic effect of (EMP) compared with (EMGAP) specially at concentrations (750 , 1000, 1500) ug/ml.

Physicochemical and microbiological characterization, and evaluation of the antimicrobial and antioxidant activity of propolis produced in two seasons and two areas of the eastern edge of the Sonoran Desert

“…Likewise, the effectiveness depends on the polyphenols structure relationship including their hydroxyl at special sites on the aromatic rings; the methylation of the hydroxyl groups; the lypopholicity of the aromatic rings; the presence of hydrophobic substituents (including alkyl chains, alkylamino chains, prenyl groups), and nitrogen or oxygen containing heterocyclic moieties. These usually enhance the activity for propolis antioxidant compounds (Xie et al, 2015;Allawi, 2019).…”